岩鹿乳康胶囊对乳腺增生大鼠血清雌孕激素的影响  

Effects of Yanlu Rukang Capsule on Estrogen and Progesterone in Serum of Rats with Hyperplasia of Mammary Glands

作　　者：郭宇飞[1] 王书勤[2] 赵素贞 周海军 Cuo Yufei;Wang Shuqin;Zhao Suzhen;Zhou Haijun(Galactophore Department,Henan Province Hospital of TCM,Zhengzhou 450002,China;Henan University of Traditional Chinese Medicine,Zhengzhou 450004 China)

机构地区：[1]河南省中医院乳腺科,郑州450002 [2]河南中医学院,郑州450004

出　　处：《世界中医药》2018年第6期1521-1524,共4页World Chinese Medicine

基　　金：河南省教育厅自然科学研究计划项目(2013B216153)

摘　　要：目的:探讨岩鹿乳康胶囊对成年雌性乳腺增生大鼠血清雌激素、孕激素水平的影响。方法:选取Wister大鼠60只,将其随机分为6组:空白组、疾病模型组、去卵巢组、三苯氧胺组、乳癖消组、岩鹿乳康胶囊组。采用酶联免疫吸附试验(ELISA)检测大鼠血清中雌二醇(E_2)和孕酮(P)水平。结果:与乳癖消组以及疾病模型组比较,岩鹿乳康组血液中E_2的水平均显著降低(P<0.05),P水平明显升高(P<0.05);与三苯氧胺组比较,岩鹿乳康组血液中E_2和P水平差异无统计学意义(P>0.05)。结论:岩鹿乳康胶囊能显著降低血中雌激素以及升高孕激素水平。Objective： To study the effects of Yanlu Rukang Capsule on estrogen and progesterone in serum of rats with hyperplasia of mammary glands.Methods： All 60 Wister rats were randomly divided into six groups： blank control group,tamoxifen group,Yanlu Rukang group,Rupixiao group,disease model group,ovariectomized group.Then,the content of estradiol（ E_2） and progesterone（ P） in serum of rats were detected by ELISA methods.Results： Compared with Rupixiao group and model group,the content of E_2 in blood in the Yanlu Rukang group was significantly decreased,and the content of P was significantly higher（ P〈0.01）; Compared with tamoxifen group,the content of E_2 and P in the blood in the Yanlu Rukang group did not significantly changed,and there was no statistical significance（ P〈0.05）.Conclusion： Yanlu Rukang capsule can significantly reduce estrogen and elevated progesterone levels in blood.

关 键 词：岩鹿乳康胶囊 大鼠 乳腺增生 雌激素 孕激素 

分 类 号：R289.5[医药卫生—方剂学]