宝安区健康育龄女性血清AMH水平及其在PCOS和POF诊疗中的应用  

Current Situation of Serum AMH Level of Healthy Women in Baoan District and its Application Value in PCOS and POF Treatment

作　　者：肖海军[1] 翟庆娜[1] 路瑞静 刘芹兰[1] 罗茗月[2] XIAO Hai-jun;ZHAI Qing-na;LU Rui-jing(Shenzhen Baoan district maternal and child care service centre,518000)

机构地区：[1]广东省深圳市宝安区妇幼保健院检验科,518000 [2]广东省深圳市宝安区妇幼保健院中心实验室,518000

出　　处：《临床输血与检验》2018年第3期279-282,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：深圳市宝安区科技局基金(No.2016cx237)资助

摘　　要：目的了解深圳宝安区健康育龄妇女血清中抗苗勒氏管激素(anti-Mullerian hormone,AMH)水平现状,并探讨其在PCOS和POF诊疗中的应用价值。方法选择同期来院就诊的多囊卵巢综合征(polycystic ovarian syndrome,PCOS)患者85例和卵巢早衰(prature ovarian failure,POF)患者67例,并选择2016年3月~2017年5月来妇幼保健院健康体检的健康育龄妇女1200例为对照组,分别检测对照组、PCOS和POF组患者治疗前及治疗3个月后血清AMH水平,并对结果进行统计分析。结果 1 200例健康育龄妇女血清AMH水平(ng/ml)为4.97±1.64,其中19~25岁组为5.41±1.38,明显高于31~35岁组和36~41岁组,差异有统计学意义(t=3.092~5.126,P<0.05);与26~30岁组的5.07±1.52比较,差异无统计学意义(t=0.906,P>0.05)。治疗前,PCOS患者AMH水平(ng/ml)为9.76±3.82,明显高于对照组、POF和围POF组,差异有统计学意义(t=13.294~29.056,P<0.01~0.001);POF组患者AMH水平(n g/m l)为0.94±0.36,明显低于对照组和围POF组,差异有统计学意义(t=2.915~11.754,P<0.05);围POF组患者AMH水平(ng/ml)为2.37±0.82,明显低于对照组,差异有统计学意义(t=8.604,P<0.05)。治疗后,PCOS,POF和围POF患者AMH水平(ng/ml)分别为5.29±1.62,4.25±1.24和4.51±1.50,与治疗前相比,差异均有统计学意义(t=7.672~11.057,P<0.05),而与对照组之间差异均无统计学意义(t=0.790~1.527,P>0.05)。结论治疗前PCOS患者血清中AMH水平明显升高,POF和围POF患者血清中明显降低,而治疗后PCOS、POF和围POF患者血清中AMH水平均恢复正常水平。因此,AMH在妇女PCOS和POF疾病诊断和治疗评价具有一定的应用价值,值得推广。Objective To investigate the current situation of anti-mullerian hormone（AMH） in healthy women of healthy childbearing age in Baoan district Shenzhen city,and to explore its application value in PCOS and POF treatment.Method We collected health check-up healthy women of childbearing age 1200 cases as control group in March 2016 to May 2017 in Shenzhen baoan district maternity and child care,and selected polycystic ovarian syndrome（PCOS）patients 85 cases and premature ovarian failure（POF）patient 67 cases at the same period,detected the serum AMH level of Control group,patients with PCOS and POF group at before the treatment and after 3-months treatment respectively,and analyzed the testing results. Results The serum AMH level of 1200 cases of healthy women of childbearing age was 4.97±1.64 ng/ml,1 9～2 5 years old group was 5.4 1±1.3 8 ng/ml,significantly higher than 31～35 and 36～41 years old group,wasstatistically significant difference（t =3.092～5.126,P〈0.05）,compared with 26～30 years old group（5.07±1.52 ng/ml） there was no statistically significant difference（t =0.906,P〈0.906）. Before the treatment,the serum AMH level of patients with PCOS was 9.7 6±3.8 2 ng/ml,significantly higher than the control group,POF and wait POF group,difference was statistically significant（t =13.294～13.294,P〈0.01～0.001）; the serum AMH level of POF patients was0.94±0.36 ng/ml,significantly lower than the control group and wait POF group,difference was statistically significant（t =2.915～2.915,P〈0.05）; the serum AMH level of wait patients was 2.3 7±0.8 2 ng/ml,significantly lower than the control group,the difference was statistically significant（t =8.604,P〈0.05）. After treatment,the serum AMH level of PCOS,POF and wait POF patients were 5.29±1.62 ng/ml,4.25±1.24 ng/ml and 4.51±1.50 ng/ml,and the difference was statistically significant between before treatment（t =7.672～11.057,P〈0.05）,compared with the control group there were no statistically significant diffe

关 键 词：育龄妇女 抗苗勒氏管激素 现状 多囊卵巢综合征 卵巢早衰 价值 

分 类 号：R711.75[医药卫生—妇产科学] R446.11[医药卫生—临床医学]