血浆脑钠肽检测在烧伤患者病情评价中的应用  

Detection of Plasma Brain Natriuretic Peptide and its Application in the Evaluation of the Severity of Burn Patients

作　　者：韩忠学[1] 刘媛媛[1] 樊霞[1] HAN Zhong-xue;LIU Yuan-yuan;PAN Xia(Laboratory Department,Liaoning Province Hospital of Chinese People＇s Armed PoHce Force 110034)

机构地区：[1]武警辽宁总队医院检验科,沈阳110034

出　　处：《临床输血与检验》2018年第4期431-434,共4页Journal of Clinical Transfusion and Laboratory Medicine

摘　　要：目的研究血浆脑钠肽(BNP)检测在烧伤患者病情评价中的应用价值。方法收集本院2015年2月～2016年3月收治的72例烧伤患者,根据我国常用的烧伤分度法将其分为轻度烧伤组(n=28,Ⅱ度烧伤面积<9%)、中度烧伤组(n=25,Ⅱ度烧伤面积10%～29%或Ⅲ度烧伤面积<10%)和重度烧伤组(n=19,烧伤总面积30%～50%或Ⅲ度烧伤面积10%～20%),分别抽取上述患者伤后24 h、48 h、72 h、96 h的静脉血标本约3 mL,采用免疫荧光法检测血BNP浓度。另选取来本院体检的20例健康者为对照组,抽取静脉血标本,比较不同烧伤程度患者血BNP的表达及变化特点。结果 72例烧伤患者血BNP在伤后24 h较正常对照组的差异无统计学意义(P>0.05),但伤后48 h、72 h、96 h血BNP检测值均较对照组有升高,差异有统计学意义(P<0.05);轻度、中度、重度烧伤组在伤后24 h血BNP检测值的差异无统计学意义(P>0.05),但48 h、72 h、96 h时血BNP值较24 h时均有升高(P<0.05);相关性分析显示烧伤程度和血BNP表达呈高度正相关(r=3.057,P<0.05)。结论烧伤患者血BNP体现出异常升高的变化特征,且和烧伤程度呈正相关,将为动态评估患者病情、指导临床治疗等提供重要参考。Objective To evaluate the value of plasma brain natriuretic peptide （BNP） in evaluating the severity of burn patients. Methods Samples were collected froln 72 cases of burn patients in our hospital froln February 2015 to March 2016, according to common burn method to divided into mild injury group （n 28, II degree burn area〈9%） , moderate burn group （n 25, II degree burn area of 10-29%, or III degree burn area〈10%） and severe burn group （n 19, total burn area of 30-50%, or III degree burn area of 10% to 20%） , about 3 lnL of venous blood salnples were drawn froln the patients with injury after 24 h, 48 h, 72 h, 96 h, respectively, immunefluorescence detection method was used to detect the blood BNP concentration, the expression level, venous blood samples froln 20 cases of healthy volunteer （fetch medical examination） in our hospital were drawn as a reference. Results BNP level in 72 cases of burn patients after 24 h, compared with the norlnal control group, hadno significant difference （P〉0.05） , but injury after 48 h, 72h, 96 h blood BNP value were significantly increased, the difference has statistical significance （P〈0.05） ; BNP value differences in minor burns, moderate burn group and severe burn group after injury in 24 h blood had no statistical significance （P〉0.05） , but at 48 h, 72 h, 96 h BNP value, compared to the 24 h, were significantly increased （P〈0.05） ; correlation analysis showed that the burn severity and plasma levels of BNP were highly positive correlation （r=3.057, P〈0.05） . Conclusion The blood BNP of burn patients reflects the characteristics of change with abnormal elevation, and is positively correlated with the degree of burn, which provides an important reference for dynamic assessment of the patient＇s condition, guiding clinical treatment and so on.

关 键 词：脑钠肽 烧伤程度 评估 

分 类 号：R446.11[医药卫生—诊断学] R644[医药卫生—临床医学]