高灵敏度血清病毒学指标检测在低病毒载量乙型肝炎人群中的应用价值  

Value of highly sensitive serum virological markers in hepatitis B patients with a low viral load

作　　者：谷九莲[1,2] 刘守胜 李昌飞 肖剑寒 辛永宁[2,5,4] 宣世英 GU Jiulian;LIU Shousheng;LI Changfei(Medical College of Qingdao University,Qingdao,Shandong 266021,China)

机构地区：[1]青岛大学医学院,山东青岛266021 [2]青岛市市立医院感染科,山东青岛266021 [3]青岛市市立医院中心实验室,山东青岛266021 [4]青岛市消化疾病重点实验室,山东青岛266071 [5]青岛市市立医院消化内二科,山东青岛266021

出　　处：《临床肝胆病杂志》2018年第6期1302-1307,共6页Journal of Clinical Hepatology

基　　金：青岛市市立医院(集团)总院长新技术;新项目创新研究基金(VIII院ZYZJJ2017013)

摘　　要：HBV的检测对于乙型肝炎的预防和治疗至关重要。临床研究发现一些乙型肝炎患者即使血清HBV DNA和HBs Ag检测阴性,病情仍会进展至肝硬化和肝细胞癌,所以迫切需要提高HBV检测的灵敏度,并发展新的检测技术和检测标志物。近年来人们逐渐意识到血清学和血清病毒学指标在低病毒载量乙型肝炎人群中的重要应用价值。主要总结了血清高灵敏度HBV DNA检测、HBs Ag、HBV RNA及血清HBcr Ag等在低病毒载量乙型肝炎人群中的临床应用价值。认为临床医生应结合乙型肝炎患者的病情及上述各项指标的检测水平与变化以指导该类人群的临床管理,最终达到治愈乙型肝炎的目的。HBV detection plays an important role in the prevention and treatment of hepatitis B. Clinical studies have shown that some patients with undetectable HBV DNA or negative HBs Ag could still progress to liver cirrhosis and hepatocellular carcinoma. Therefore,it is urgent to improve the sensitivity of HBV detection and develop new technologies and biomarkers for HBV detection. In recent years,we gradually realize the important value of serological and serum virological markers in hepatitis B patients with a low viral load. This article summarizes the value of some highly sensitive serum markers（HBV DNA,HBs Ag,and HBV RNA） and serum HBcr Ag in hepatitis B patients with a low viral load. It is pointed out that clinicians should guide the clinical management of such patients with reference to their conditions and the changes in above markers,in order to realize the cure of hepatitis B.

关 键 词：肝炎病毒 乙型 肝炎 乙型 慢性 病毒载量 血液学试验 综述 

分 类 号：R512.62[医药卫生—内科学]