股骨近端骨折术后丹参川芎嗪治疗对TXA2/PGI2、骨代谢及应激程度的影响  

Effects of Danshen Chuanxiongqin therapy on TXA2/PGI2,bone metabolism and stress levels after proximal femoral fracture surgery

作　　者：史晓娟 杨卫红[2] SHI Xiao-juan;YANG Wei-hong(Department of Orthopedics,the First Affiliated Hospital of the Fourth Military Medical University,Xi＇an,Shaanxi Province,710032;Department of Quality Management,No.451 Hospital of PLA,Xi＇an,Shaanxi Province,710054,China)

机构地区：[1]空军军医大学第一附属医院骨科,陕西西安710032 [2]解放军第451医院质量管理科,陕西西安710054

出　　处：《海南医学院学报》2018年第10期1006-1009,1014,共5页Journal of Hainan Medical University

基　　金：全军医药卫生科研基金课题(CLZ12JB34)~~

摘　　要：目的:研究股骨近端骨折术后丹参川芎嗪治疗对TXA2/PGI2、骨代谢及应激程度的影响。方法:选择空军军医大学第一附属医院2015年1月~2016年12月期间进行切开复位内固定治疗的股骨近端骨折患者80例作为研究对象,随机分为术后给予丹参川芎嗪辅助治疗的实验组、术后给予常规治疗的对照组。手术前及手术后3天时,测定血清中TXA2/PGI2平衡相关指标、骨代谢指标、应激激素的含量及外周血中应激分子的表达量。结果:与组内手术前比较,两组患者手术后血清中6-ketoPGF1α、t-PA、PICP、BALP、OCN的含量显著降低,血清中TXB2、PAI-1、D-D、β-CTX、RANKL、NE、COR、ANG-II的含量及外周血中NF-κB、HSP70的表达量显著升高(P<0.05)且实验组患者手术后血清中6-keto-PGF1α、t-PA、PICP、BALP、OCN的含量高于对照组,血清中TXB2、PAI-1、D-D、β-CTX、RANKL、NE、COR、ANG-II的含量及外周血中NF-κB、HSP70的表达量低于对照组。结论:股骨近端骨折术后丹参川芎嗪治疗能够调节TXA2/PGI2平衡、改善骨代谢、减轻应激程度。Objective：To study the effects of Danshen Chuanxiongqin therapy on TXA2/PGI2,bone metabolism and stress levels after proximal femoral fracture surgery.Methods：80 patients with proximal femoral fractures who received open reduction and internal fixation treatment in the First Affiliated Hospital of the Fourth Military Medical University between January 2015 and December 2016 were selected as the research subjects and randomly divided into the experimental group who received postoperative adjuvant Danshen Chuanxiongqin therapy and the control group who received postoperative conventional therapy.The levels of TXA2/PGI2 balance-related indicators,bone metabolism indicators and stress hormones in serum as well as the expression levels of stress molecules in peripheral blood were measured before surgery and 3 days after surgery.Results：Compared with those of same group before surgery,serum 6-keto-PGF1α,t-PA,PICP,BALP and OCN levels of both groups of patients were significantly lower whereas serum TXB2,PAI-1,D-D,β-CTX,RANKL,NE,COR and ANG-II levels as well as peripheral blood NF-κB and HSP70 expression were significantly higher after surgery（P0.05）,and serum 6-ketoPGF1α,t-PA,PICP,BALP and OCN levels of experimental group after surgery were higher than those of control group whereas serum TXB2,PAI-1,D-D,β-CTX,RANKL,NE,COR and ANG-II levels as well as peripheral blood NF-κB and HSP70 expression were lower than those of control group.Conclusion：Danshen Chuanxiongqin therapy after femoral proximal fracture surgery can adjust the TXA2/PGI2 balance,improve the bone metabolism and reduce the stress level.

关 键 词：股骨近端骨折 丹参川芎嗪 深静脉血栓形成 骨代谢 应激反应 

分 类 号：R683[医药卫生—骨科学]