男性高尿酸血症患者不同糖耐量状态下成纤维细胞因子21与血尿酸的关系  

Relationship of serum fibroblast growth factor-21 and uric acid in male hyperuricemia patients with different glucose metabolism status

作　　者：赵江波[1] 王蓓[1] 杨玲[1] 尹卫[1] 李林[1] 丁伟[1] ZHAO diangbo;WANG Bei;YANG Ling;YIN Wei;LI Lin;DING Wei(Department of Endocrinology,Affiliated Hospital to d iangsu University,Zhenj iang,d iangsu 212001,China)

机构地区：[1]江苏大学附属医院内分泌科,江苏镇江212001

出　　处：《检验医学与临床》2018年第15期2247-2250,共4页Laboratory Medicine and Clinic

摘　　要：目的分析男性高尿酸血症(HUA)患者不同糖耐量状态下血清成纤维细胞因子21(FGF21)水平的变化及与血尿酸(SUA)的关系。方法 98例HUA男性患者纳入HUA组,并根据血糖情况分为HUANGT亚组(正常糖耐量,30例)、HUA-IGR亚组(糖调节受损,32例)及HUA-T2DM亚组(2型糖尿病,36例)。90例体检健康男性纳入对照组。检测所有研究对象FGF21、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、餐后2h血糖(2hPG)、血压、血脂、胰岛素抵抗指数自然对数[ln(HOMA-IR)]、腰臀比(WHR)、空腹胰岛素(FINS)等指标。结果 HUA组、对照组FGF21水平分别为(1.99±0.97)、(1.73±0.45)ng/mL,HUA组明显高于对照组,差异有统计学意义(P<0.05)。HUA-T2DM亚组、HUA-IGR亚组、HUA-NGT亚组FGF21水平分别为(2.61±0.45)、(1.89±0.71)、(1.01±0.69)ng/mL,HUA-T2DM亚组、HUA-IGR亚组均明显高于HUANGT亚组,差异有统计学意义(P<0.05)。FGF21水平与FPG、2hPG、HbA1c、WHR、三酰甘油、ln(HOMAIR)、FINS、SUA呈正相关(r=0.558、0.478、0.387、0.401、0.334、0.256、0.220、0.221,P<0.05)。FPG、2hPG、WHR、SUA、ln(HOMA-IR)、三酰甘油是FGF21的独立影响因素(P<0.05)。结论男性HUA患者FGF21水平升高,FGF21可能参与了男性HUA患者糖代谢调节。Objective To investigate the relationship of serum fibroblast growth factor 21 （FGF21） and se rum uric acid （SUA） in male hyperuricemia patients with different glucose metabolism status. Methods A to tal of 98 HUA patients were recruited into HUA group,and divided into HUA NGT subgroup （normal glu cose tolerance,n=30）,HUA IGR subgroup （impaired glucose tolerance,n=32） and T2DM subgroup （newly diagnosed T2DM,n=36）according to the 75 g OGTT results, 90 healthy male were recruited into control group. All objects were measured FGF21 ,hemoglobin Alc （HbAlc）,fasting blood glucose （FPG）,2 h blood glucose after meal（2 hPG）,blood pressure,blood lipid and ln（HOMA IR）,waist to hip ratio （WHR）,fasting insulin （FINS）. Results Serum FGF21 level in HUA group was significantly higher than that in control group[（1.99±0.97）＇vs. （1.73＋0. 45）ng/mL,P〈0. 05]. Serum FGF21 level in HUA T2DM subgroup and HUA IGR subgroup were also significant higher than that in HUA NGT subgroup [（2.61±0.45）＇vs. （1.89± 0.71）＇vs. （1.01±0. 69）ng/mL,P〈0. 05]. The FGF21 level positively correlated with FPG,2 hPG, HbAlc, WHR,triacylglycerol,ln（HOMA IR ）,FINS and SUA（r=0. 558,0. 478,0. 387,0. 401,0. 334,0. 256,0. 220, 0. 221,P〈0.05）. Multiple linear stepwise regression analysis showed FPG,2 hPG,WHR,SUA,ln（HOMA IR） and triacylglycerol were independent factors of the FGF21 （P〈0.05）. Conclusion FGF21 might contrib ute to glucose metabolism regulation since it increases in male HUA patients.

关 键 词：糖代谢 高尿酸血症 男性 成纤维细胞因子21 血尿酸 

分 类 号：R587.1[医药卫生—内分泌]