血清C反应蛋白及甲胎蛋白在新生儿病理性黄疸诊断及预后中的价值  

Value of serum C reactive protein andα-fetal protein in the diagnosis and prognosis of neonatal pathologic jaundice

作　　者：黄学晓 张世民 辜德明 HUANG Xuexiao;ZHZNG Shimin;GU Derning(Department of Pediatric,the Second Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570311,China）HUANG Xuexiao,ZHANG Shimin,GU Deming（Department of Pediatric,the Second Affiliated Hospital of Hainan Medical University,Haikou,Hainan 570311,China)

机构地区：[1]海南医学院第二附属医院儿科,海口570311

出　　处：《检验医学与临床》2018年第15期2266-2268,2271,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨血清C反应蛋白(CRP)、甲胎蛋白(AFP)在新生儿病理性黄疸诊断及预后判断中的价值。方法选择该院儿科收治的258例黄疸新生儿作为研究对象,其中132例病理性患儿纳入病理组,126例生理性黄疸新生儿纳入生理组,选择同期的50例健康新生儿纳入对照组。病理组患儿均接受常规对症治疗。比较各组新生儿的总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、CRP、AFP水平。结果病理组治疗前和生理组的TBIL、DBIL、IBIL、AFP水平均明显高于对照组,差异有统计学意义(P<0.05);病理组治疗前的TBIL、DBIL、IBIL、AFP水平均明显高于生理组,差异有统计学意义(P<0.05);病理组治疗前的CRP水平明显高于生理组、对照组,差异有统计学意义(P<0.05);病理组治疗后TBIL、DBIL、IBIL、CRP、AFP水平均较治疗前明显下降,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,在病理组患儿中,血清CRP水平与血清TBIL、IBIL水平,血清AFP水平与血清TBIL、DBIL、IBIL水平均呈显著正相关(P<0.05)。结论黄疸新生儿的血清CRP、AFP水平均会异常上升,特别是病理性黄疸变化更为明显,对于病理性黄疸的诊断及其预后判断具有一定的参考意义。Objective To investigate the value of serum C reactive protein （CRP） and a-fetal protein （AFP） in the diagnosis and prognosis of neonatal pathologic jaundice. Methods A total of 258 patients with neonatal jaundice were selected as objects in this study, 132 cases with pathological jaundice in the pathological group, 126 cases with physiological jaundice in the physical group, and 50 healthy neonates were selected as the control group. The patients with pathological jaundice were treated with conventional symptomatic treatment. The levels of total bilirubin （TBIL）, direct bilirubin （DBIL）, indirect bilirubin （IBIL）, CRP, AFP of all groups were analyzed and compared. Results The levels of TBIL,DBIL,IBIL and AFP in pathological group before treatment and physical group were all significantly higher than those of control group （P〈0. 05） ,and the lev els of TBIL,DBIL,IBIL and AFP in pathological group before treatment were significantly higher than those in physical group （P〈0.05）. The CRP level in pathological group before treatment was significantly higher than those in physical group and the control group （P〈0.05）. After the appropriate treatment, the TBIL, DBIL,IBIL,CRP,AFP levels of pathological group decreased significantly than those before treatment （P〈 0.05）. Pearson correlation analysis showed that there were significant positive correlation between serum CRP and TBIL,IBIL,between serum AFP and TBIL,DBIL,IBIL in patients with neonatal jaundice （P〈0.05）. Conclusion Serum CRP and AFP levels in patients with neonatal jaundice increased abnormally, especially changes in pathological jaundice patients,which has a certain reference for the diagnosis and prognosis of neo natal pathologic jaundice.

关 键 词：黄疸 胆红素 C反应蛋白 甲胎蛋白 新生儿 

分 类 号：R722.17[医药卫生—儿科]