隔药灸联合雷诺考特鼻喷雾剂治疗脾虚型持续性中重度变应性鼻炎随机对照研究  

A Randomized Controlled Clinical Trial of Treatment of Moderate and Severe Persistent Allergic Rhinitis of Spleen Deficiency Pattern by Herbal Cake-partitioned Moxibustion Combined with Rhinocort Nasal Spray

作　　者：曲舒涵 赵吉平[1] 陈晟[1] 温志宏[1] 张怡[2] 侯学思 曾炜美 贾一凡 景向红[3] QU Shu-han;ZHAO Ji-ping;CHEN Sheng;WEN Zhi-hong;ZHANG Yi;HOU Xue-si;ZENG Wei-mei;JIA Yi-fan;JING Xiang-hong(Derpartment of Acupuncture moxibustion,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Derpartment of Otorhinolaryngology,Chaoyang Hospital,Capital Medical University,Beijing 100020;Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700)

机构地区：[1]北京中医药大学东直门医院针灸科,北京100700 [2]首都医科大学附属北京朝阳医院耳鼻喉科,北京100020 [3]中国中医科学院针灸研究所,北京100700

出　　处：《针刺研究》2018年第7期450-455,共6页Acupuncture Research

基　　金：北京市自然科学基金(No.7164272);北京中医药科技发展基金项目(No.JJ 2015-62)

摘　　要：目的:评价隔药灸联合雷诺考特鼻喷雾剂治疗脾虚型持续性中重度变应性鼻炎的临床疗效。方法:60例中重度变应性鼻炎患者随机分为雷诺考特组和隔药灸联合雷诺考特组,各30例。雷诺考特组予雷诺考特鼻喷雾剂鼻腔局部用药,每日每侧鼻孔2喷(每喷64!g),连续治疗8周。隔药灸联合雷诺考特组在此基础上加用隔药灸治疗,取印堂、足三里、合谷、神阙,隔日治疗1次,每周3次,连续治疗8周。观察两组患者治疗前、治疗4周、治疗8周和治疗结束后4周的鼻部症状视觉模拟量尺(VAS)评分、鼻结膜炎患者生活质量问卷(RQLQ)评分、脾虚症状积分,并比较两组的临床疗效。结果:两组治疗4周鼻部症状VAS评分、RQLQ评分、脾虚症状积分较本组治疗前均降低(P<0.01,P<0.05),治疗8周较治疗4周鼻部症状VAS评分、RQLQ评分、脾虚症状积分均有降低(P<0.05,P<0.01),治疗结束后4周与治疗8周相比,两组患者鼻部症状VAS评分、RQLQ评分、脾虚症状积分均有一定程度的升高(P<0.01,P<0.05),治疗结束后4周隔药灸联合雷诺考特组鼻部症状VAS评分、RQLQ评分较雷诺考特组降低(P<0.05)。隔药灸联合雷诺考特组、雷诺考特组总有效率分别为86.7%(26/30)、83.3%(25/30),差异无统计学意义(P>0.05)。结论:隔药灸联合鼻喷激素与单用鼻喷激素均可有效治疗脾虚型持续性中重度变应性鼻炎,与单用鼻喷激素相比,隔药灸联合鼻喷激素对治疗后疗效的维持更有优势。Objective To evaluate the clinical effect of herbal cake-partitioned moxibustion combined with medication in the treatment of moderate and severe persistent allergic rhinitis（PAR）patients of spleen deficiency pattern.Methods Sixty patients with moderate and severe PAR of spleen deficiency pattern were randomized into medication（Rhinocort）group and herbal cake-partitioned moxibustion combined with medication group（combination group,n=30 cases in each）.Medicinal cake-partitioned moxibustion was applied to Yintang（GV 29,for about 20 min）,Shenque（CV 8,about 50 min）,bilateral Zusanli（ST 36,about 40 min）and Hegu（LI 4,about 40 min）once every other day for successive 8 weeks.All the patients received treatment with Rhinocort nasal spray,2 jets/day for each nostril（64 !g/jet）for 8 weeks.The patients＇ conditions（symptoms of nasal sufferings,sleeping,sniffle,eye,emotion,etc.）were assessed by visual analogue scale（VAS）and rhino conjunctivitis quality of life questionnaire（RQLQ,24 items of 7 aspects,0-6 points/item）,respectively.The spleen deficiency syndrome score was determined according to＂Guiding Principles for Clinical Research of New Drugs of Chinese Materia Medica＂（2002）.The therapeutic effect was assessed by referring to＂the Diagnostic and Therapeutic Principles and Recommended Schemes for Allergic Rhinitis＂（2004）.Results Following the treatment,the scores of VAS,RQLQ,spleen deficiency syndrome were significantly decreased on the 4 thand the 8 th week of treatment in both groups in comparison with those of their own individual pre-treatment（P〈0.05,P〈0.01）.Four weeks＇ follow-up survey showed that the VAS score and RQLQ score of the combination group were obviously lower than those of the medication groups（P〈0.05）,suggesting a better post-effect of moxibustion.Of the two 30 cases in the medication and combination groups,9 and 9 experienced marked improvement in their symptoms,16 and 17 were effective,and5 and 4 ineffective,with the effective r

关 键 词：变应性鼻炎 隔药灸 联合疗法 随机对照研究 

分 类 号：R245.8[医药卫生—针灸推拿学]