急性百草枯中毒患者肺部感染病原菌分布与药敏情况及治疗的研究  

Distribution and drug susceptibility of pathogens causing pulmonary infection in patients with acute paraquat poisoning and treatment measures

作　　者：陈红纲[1] 付晓燕[2] 杨蓉佳[1] 李永胜[1] 王彬彬 CHEN Hong-gang;FU Xiao-yan;YANG Rong-jia;LI Yong-sheng;WANG Bin-bin(Gansu Provincial People＇s Hospital,Lanzhou,Gansu 730000,Chin)

机构地区：[1]甘肃省人民医院急诊科,甘肃兰州730000 [2]兰州大学第一医院护理部,甘肃兰州730000

出　　处：《中华医院感染学杂志》2018年第13期1951-1953,共3页Chinese Journal of Nosocomiology

摘　　要：目的分析急性百草枯中毒患者肺部感染病原菌分布及药敏情况。方法选取2011年1月-2016年1月收治的114例急性百草枯中毒合并肺部感染患者,采用全自动微生物分析仪对痰液样本进行菌种鉴定,分析病原菌种类并进行药敏试验。结果 114例百草枯中毒合并肺部感染患者共分离病原菌169株,其中肺炎链球菌及肺炎克雷伯菌占比最高,分别为16.57%及14.79%;革兰阴性菌中肺炎克雷伯菌、大肠埃希菌及鲍氏不动杆菌占比最高,对亚胺培南敏感;革兰阳性菌中肺炎链球菌、金黄色葡萄球菌占比最高,对万古霉素敏感;真菌中白假丝酵母、光滑假丝酵母占比最高,对两性霉素B敏感。结论百草枯中毒合并肺部感染患者感染病原菌以肺炎链球菌及肺炎克雷伯菌为主,应通过药物敏感试验合理选择抗菌药物,针对性的个体化给药,提供有效药物治疗。OBJECTIVE To investigate the distribution and drug susceptibility of pathogens causing pulmonary infection in patients with acute paraquat poisoning.METHODS A total of 114 acute paraquat poisoning patients complicated with pulmonary infection who were treated from Jan 2011 to Jan 2016 were enrolled in the study,the pathogens isolated from sputum specimens were identified by using automatic microorganism analyzer,the species of the isolated pathogens were analyzed,and the drug susceptibility testing was performed.RESULTS A total of169 strains of pathogens were isolated from the 114 paraquat poisoning patients complicated with pulmonary infection,16.57% of which were Streptococcus pneumoniae,14.79% were Klebsiella pneumoniae.K.pneumoniae and Acinetobacter baumannii were the predominant species of the gram-negative bacteria and were susceptible to imipenem.S.pneumoniae and Staphylococcus aureus were dominant among gram-positive bacteria and were susceptible to vancomycin.Candida albican and Candida glabrata were the predominant species of fungi and were susceptible to amphotericin B.CONCLUSIONS.pneumoniae and K.pneumoniae are dominant among the pathogens isolated from the acute paraquat poisoning patients complicated with pulmonary infection.It is necessary to reasonably use antibiotics based on the drug susceptibility testing,carry put the individualized drug administration and provide effective drug therapy.

关 键 词：百草枯中毒 肺部感染 病原菌分布 药敏情况 

分 类 号：R378[医药卫生—病原生物学]