CARD9突变在真菌感染性疾病中的研究进展  

Progress in CARD9 mutation and fungal infections

作　　者：张逸 王晓雯[1] 李若瑜[1] ZHANG Yi;WANG Xiaowen;LI Ruoyu(Department of Dermatology and Venereology,Peking University First Hospital,Research Center for Medical Mycology,Peking University,Beijing Key Laboratory of Molecular Diagnosis of Dermatoses,Beijing 100034,China)

机构地区：[1]北京大学第一医院皮肤性病科北京大学真菌与真菌病研究中心皮肤病分子诊断北京市重点实验室,北京100034

出　　处：《微生物与感染》2018年第4期233-244,共12页Journal of Microbes and Infections

基　　金：国家自然科学基金(81472890)

摘　　要：胱天蛋白酶募集域蛋白9(caspase recruitment domain-containg protein 9,CARD9)属于CARD家族中的一员,存在于脾、肝、胎盘、肺、脑等人体多种组织中,是高度表达于中性粒细胞、巨噬细胞及树突细胞等髓系细胞中的一个重要衔接蛋白。CARD9可与Bcl-10、黏膜相关淋巴组织淋巴瘤转运蛋白1(mucosaassociated lymphoid tissue lymphoma translocation protein 1,MALT-1)结合并形成CARD9-Bcl-10-MALT-1(CBM)复合体,作为C型凝集素受体(C-type lectin receptor,CLR)等通路的重要媒介,激活核因子κB(nuclear factorκB,NF-κB)等炎症信号通路,在抗真菌免疫中发挥重要作用。迄今为止,全世界已报道14个国家共56例患者发生18种CARD9突变的报道,真菌类型涉及念珠菌、皮肤癣菌、暗色真菌及曲霉等。本文针对CARD9突变在不同真菌感染性疾病中的研究进展进行综述。Caspase recruitment domain-containing protein 9 （CARD9）, one of the CARD family members, is an essential adapter in myeloid cells, and is expressed in various tissues, including the spleen, liver, placenta, lung and brain. By forming a complex with Bcl-10 and mucosa-associated lymphoid tissue lymphoma translocation protein 1 （MALT1）, CARD9 mediates C-type lectin receptors （CLRs）-triggered intracellular signaling and nuclear factor κ B （NF- κ B） activation, which is therefore crucial in antifungal immunity. Evidence indicates that CARD 9 mutations lead to increased susceptibility to various fungal infections. To date, 18 missense and nonsense CARD 9 mutations have been reported in 56 patients from 14 countries, which is linked with a variety of fungal infections including Candida , Dermatophytes, Dematiaceous fungi, Aspergillus , etc. This review aims to summarize recent progress in CARD 9 mutation and different fungal infections.

关 键 词：胱天蛋白酶募集域蛋白9 真菌感染 念珠菌 皮肤癣菌 暗色真菌 曲霉 

分 类 号：R519[医药卫生—内科学]