消脂清肝颗粒剂质量标准研究  

Quality standard of Xiaozhi Qinggan granules

作　　者：冯月男[1] 孙思邈[1] 刘珍[1] 张玉昆[1] FENG Yue-nan;SUN Si-miao;LIU Zhen;ZHANG Yu-kun(Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《化学工程师》2018年第7期24-27,共4页Chemical Engineer

基　　金：国家自然科学基金(81473555;81703981);黑龙江省博士后科研启动金资助项目(LBH-Q16213);黑龙江省普通本科高等学校青年创新人才培养计划(UNPYSCT-2016077);黑龙江省教育厅国自然配套项目(2017PT07);黑龙江中医药大学科研基金项目(201739)

摘　　要：目的建立消脂清肝颗粒剂的质量标准。方法对消脂清肝颗粒剂中丹参、枳实进行了薄层色谱鉴别实验,采用高效液相法测定丹酚酸B含量。结果丹酚酸B在2.7~18.9μg之间与峰面积呈良好的线性关系,精密度试验RSD值小于2%,有效成分8h内稳定,重现性较好,平均回收率在95%~105%之间,RSD值小于3%。结论该方法可以有效的控制消脂清肝颗粒剂的质量。Objective： Establish the quality standard of Xiaozhiqinggan granules. Methods： Thin-layer chroatography was used to discriminate Salvia miltiorrhiza Bge., Fructus Aurantii and Radix Paeoniae Alba in the Xiaozhi Qinggan granules. Salvianolic acid B content was determined by HPLC. RESULTS： There was a good linear relationship between the peak area and the content of salvianolic acid B between 2.7 and 18.9μg. The RSD value of the precision test was less than 2%. The active ingredient was stable within 8 hours with good reproducibility. The average recovery was 95%-105%, the RSD value is less than 3%. Conclusion： This method can effectively control the quality of Xiaozhiqinggan granules.

关 键 词：脂肪肝 消脂清肝颗粒剂 质量标准 薄层色谱 高效液相色谱 

分 类 号：R286.0[医药卫生—中药学]