稀土元素对江西赣南地区稀土暴露人群肾结石形成的影响初步研究  

Initial investigation of the effect of rare earth on renal stone in Jiangxi province Gannan district

作　　者：徐瑞权[1] 刘全亮[1] 邹晓峰[1] 王共先[2] 张国玺[1] 袁源湖[1] 肖日海[1] 刘佛林[1] 黎衍敏[1] 曾晓鹏[1] 曾庆明[1] 杨增祥[1] 刘林伟[1] XU Ruiquan;LIU Quanliang;ZOU Xiaofeng;WANG Gongxian;ZHANG Guoxi;YUAN Yuanhu;XIAO Rihai;LIU Folin;LI Yanmin;ZENG Xiaopeng;ZENG Qingming;YANG Zengxiang;LIU Linwei(Department of Urology,First Affiliated Hospital of Gannan Medical University,Ganzhou,Jiangxi,341000,China;Department of Urology,First Affiliated Hospital of Nanchang University)

机构地区：[1]赣南医学院第一附属医院泌尿外科,江西省结石防治工程技术研究中心,江西赣州341000 [2]南昌大学第一附属医院泌尿外科

出　　处：《临床泌尿外科杂志》2018年第7期567-570,共4页Journal of Clinical Urology

基　　金：江西省"赣鄱英才555工程"领军人才培养计划项目;江西省科技厅科技计划项目(编号2010BSA10400;20132BBG70089);江西省高校"十二五"重点学科建设经费资助项目;江西省卫生计生委科技计划项目(编号20155440)

摘　　要：目的:初步探讨稀土元素(rare earth,RE)与江西赣南地区稀土暴露人群泌尿系结石形成的影响。方法:随机选择180例江西赣南稀土暴露地区肾结石患者为研究组和180例非稀土暴露地区肾结石患者为对照组,剔除继发性肾结石,包括胱氨酸结石、尿酸盐结石及磷酸盐结石,研究组共173例,对照组171例。分别采用电感耦合等离子体发射光谱法和美国PE公司EAAN-5000型电感耦合等离子体质谱仪(ICP-MS)检测两组患者肾结石标本和血浆中RE的含量。结果:研究组肾结石中镝(Dy)、镱(Yb)、铥(Tm)、钆(Gd)、铒(Er)元素的含量显著高于对照组(P<0.05)。研究组血浆中Dy、Yb、Tm、镥(Lu)、镨(Pr)、钕(Nd)浓度显著高于对照组(P<0.05)。而镧(La)、铈(Ce)、钐(Sm)、铕(Eu)、铽(Tb)、钬(Ho)等元素的含量在两组间差异均无统计学意义(P>0.05)。结石成分分析中,剔除继发性结石,研究组以混合性结石成分为主,对照组中以单纯性草酸钙成分为主,差异有统计学意义(P<0.05)。结论:Dy、Yb、Tm等元素可能影响江西赣南地区稀土暴露人群尿路结石的形成。Objective：To investigate the effect of rare earth on the formation of urolithiasis in rare earth exposure population from Jiangxi province Gannan district.Method：The rare earth exposed renal stone patients from Jiangxi province Gannan district were randomly selected as the research group（180 cases）,and rennal stone patients in non-rare earth exposed were selected as control group（180 cases）.The secondary renal stones were removed,including cystine stone,uric acid stone and phosphate stone.There were 173 cases in research group and171 cases in control group.We detected the rare earth elements in stone（μg/g）and blood plasma（mmol/L）.The content of rare earth elements in the calculus was detected by inductively coupled plasma atomic emission spectrometry.Detection of rare earth elements in blood plasma by American company PE EAAN-5000 inductively coupled plasma mass spectrometry（ICP-MS）was done.Result：Dysprosium,ytterbium,thulium,gadolinium and erbium in stone in research group were higher than those in control group（P〈0.05）.Dysprosium,ytterbium,thulium,lutetium,praseodymium and neodymium in plasma in research group were significantly higher than those in control group（P〈0.05）.But there was no significant difference in lanthanum,cerium,samarium,europium,terbium and holmium between the two groups（P〈0.05）.Removal of secondary stones for calculus composition analysis,the research group was mainly composed of mixed stones,and the control group was mainly composed of simple calcium oxalate,and the difference was statistically significant（P〈0.05）.Conclusion：Dysprosium,ytterbium and thulium may be the causes of evoked urinary stone in rare earth exposure population from Jiangxi province Gannan district.

关 键 词：稀土 结石 病因分析 

分 类 号：R692.4[医药卫生—泌尿科学]