嗅上皮干细胞分化、发育中转录因子功能的研究现状  

The role of transcription factors in differentiation and development of the olfactory epithelium stem cells

作　　者：徐赫 梁才全 徐亚平 范静平 郎军添 cells Xu He;Liang Caiquan;Xu Yaping;Fan Jingpiag;Lang Juntian(Department of Otorhinolaryngology Head and Neck Surgery,the Naval Medical University Affiliated Chang Zheng Hospital,Shanghai 200003,Chin)

机构地区：[1]海军军医大学附属长征医院耳鼻咽喉头颈外科,上海200003

出　　处：《中华耳鼻咽喉头颈外科杂志》2018年第7期550-554,共5页Chinese Journal of Otorhinolaryngology Head and Neck Surgery

基　　金：上海市自然科学基金（16ZR1437000）;上海市卫计委科研基金（2013434）

摘　　要：嗅上皮既是嗅觉系统的感受器，又是哺乳动物体内唯一能够终生保持自我更新能力的神经性上皮，对神经组织的再生与修复、神经干细胞的移植与治疗、嗅觉障碍的发病与干预的研究都具有十分重要的意义。本文将阐述嗅上皮干细胞的特点，并针对各转录因子在嗅上皮干细胞发育和分化过程中发挥的功能和意义展开综述，以期为嗅上皮干细胞的研究提供新思路。As a sensor of the olfactory system, olfactory epithelium plays an important role in the olfactory system. In addition, olfactory epithelium is the only neuroepithelial epithelium in mammals that can maintain its self-renewal all along. There are of great significance in researching regenerating and repairing neural tissues, transplanting and treatment neural stem cells as well as the occurrence of olfactory disorders and intervention. This review will describe the characteristics of olfactory epithelial stem cells, and mainly summerize the function and significance of each transcription factor in the process of olfactory epithelial stem cell development and differentiation, in order to provide new ideas for the study of olfactory epithelial stem cells.

关 键 词：嗅黏膜 干细胞 转录因子 

分 类 号：R339.12[医药卫生—人体生理学]