青光眼生物力学研究进展  

Advances in glaucoma biomechanics research

作　　者：钱秀清 宋红芳 刘志成 QIAN Xiuqing;SONG Hongfang;LIU Zhicheng(Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Applicatio;School of Biomedical Engineering,Capital Medical University,Beijing 100069,Chin)

机构地区：[1]首都医科大学生物医学工程学院临床生物力学应用基础研究北京市重点实验室

出　　处：《科技导报》2018年第13期30-38,共9页Science & Technology Review

基　　金：国家自然科学基金项目(31570952,31670964,10802053);北京市自然科学基金项目(7152022)

摘　　要：青光眼是全球第一位不可逆性致盲眼病,高眼压是视功能损伤的主要危险因素,降眼压是目前青光眼治疗的主要手段。生物力学问题是青光眼致病机制、预防和治疗研究的重要内容。小梁网房水外流阻力增大是眼压升高的主要因素,眼压升高将导致虹膜变形、瞳孔阻滞、眼前房房水流场改变、视神经纤维层及筛板厚度变薄、视功能损伤等。本文从眼压测量、房水流场测量、视功能损伤等方面综述了近年来青光眼生物力学的研究进展。Glaucoma ranks the first in the irreparable blindness eye diseases in the world. As the elevated intraocular pressure is the main risk factor of visual impairment, decreasing intraocular pressure is the main treatment of glaucoma at present. Therefore, the biomechanical problem of glaucoma is an important part of the research of pathogenesis, prevention and treatment of glaucoma. The main reason of high intraocular pressure for glaucoma is the increase of outflow resistance of aqueous humor. The increase of intraocular pressure will lead to iris deformation, pupil block, change of flow field of aqueous humor in the anterior chamber, thinning thickness of optic nerve fiber layer and lamina cribrosa, and damage of＇ visual function. Recent advances in glaucoma biomechanics are introduced from aspects of intraocular pressure measurement, measurement of aqueous humor flow, visual function imparied, etc.

关 键 词：高眼压 小梁网 房水 视网膜 视功能 

分 类 号：R318.01[医药卫生—生物医学工程] R775[医药卫生—基础医学]