γ–聚谷氨酸/海藻酸钠双网络水凝胶的制备及性能研究  

Study on preparation and performance of poly(γ-glutamic acid)/sodium alginate double network hydrogel

作　　者：朱享波 武欣[1] 杨国强 汪建新[1] Zhu Xiangbo, Wu Xin, Yang Guoqiang, Wang Jianxin(School of Materials Science and Engineering, Southwest Jiaotong University, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Chengdu 610031, Chin)

机构地区：[1]西南交通大学材料科学与工程学院西南交通大学材料先进技术教育部重点实验室

出　　处：《化学推进剂与高分子材料》2018年第4期68-73,共6页Chemical Propellants & Polymeric Materials

基　　金：中国国家自然科学基金(NO.51072167和NO.31370966);中国国家重点技术研究发展计划(2016YFC110200和2016YFC110201)资助

摘　　要：采用两步法合成了γ–聚谷氨酸（PGA）/海藻酸钠（SA）双网络水凝胶,其中化学交联的PGA–Ly（赖氨酸）网络作为第一网络,而离子交联的SA–Ca2＋网络作为第二网络。通过控制水凝胶的弹性张力和溶胀率之间的平衡,很好地控制了PGA/SA水凝胶的溶胀。通过傅里叶变换红外光谱（FTIR）对水凝胶结构进行了表征。压缩试验结果表明,PGA/SA水凝胶的压缩模量（0.17 MPa）为PGA水凝胶（0.034MPa）的5倍。拉伸试验结果显示,当SA质量浓度达到0.02 g/m L时,PGA/SA水凝胶的断裂伸长率和拉伸强度分别为PGA水凝胶的2倍和8倍。溶胀试验结果表明,随SA含量增加,水凝胶溶胀率逐渐下降。这些特性表明PGA/SA水凝胶在组织工程中具有巨大的应用潜力。The poly（γ-glutamic acid）（PGA）/sodium alginate（SA） double network hydrogel was synthesized by two-step method using the chemical crosslinked PGA-Ly（lysine） network as the first network and the ion-crosslinked SA-Ca2＋ network as the second network. The swelling of PGA/SA hydrogel can be well controlled through manipulating the equilibrium between the elastic tension and swelling rate of the hydrogel. The structure of the hydrogel was characterized by using Fourier transform infrared（FTIR） spectrum. The compression test result shows that the compression modulus（0.17 MPa） of PGA/SA hydrogel is 5 times of that（0.034 MPa） of the PGA hydrogel. The tensile test result shows that when the mass concentration of SA achieves 0.02 g/mL, the elongation at break and the tensile strength of PGA/SA hydrogel are 2 times and 8 times of those of PGA hydrogel respectively. The swelling test result shows that the swelling rate of hydrogel decreases gradually with increasing of SA content. These characteristics show that PGA/SA hydrogel possesses great application potential in the tissue engineering.

关 键 词：γ–聚谷氨酸 海藻酸钠 水凝胶 双网络 高力学性能 

分 类 号：TQ427.26[化学工程]