重叠综合征患者尿微量白蛋白的改变及临床意义  

Change of microalbuminuria in patients with overlap syndrome and its clinical significance

作　　者：刘佳[1] 贾俊青 Liu Jia1;Jia Junqing2(1. Shanxi Medical University, Taiyuan 030001, China ; 2.Department of Respiratory Medicine, Shanxi Provincial Fenyang Hospital, Fenyang 032200, Chin)

机构地区：[1]山西医科大学,太原030001 [2]山西省汾阳医院呼吸内科,032200

出　　处：《中国医师杂志》2018年第7期1116-1119,共4页Journal of Chinese Physician

摘　　要：慢性阻塞性肺疾病(COPD)与阻塞性睡眠呼吸暂停低通气综合征(OSAS)并存称为重叠综合征(OS),相比单一的COPD或OSAS患者,OS患者有更为严重的与夜间睡眠相关的低氧血症,表现出更为严重的肺功能受损和肺动脉高压,预后更差。提高对OS的认识,使OS患者得到及时的诊断和治疗,具有重要的临床意义。尿微量白蛋白(MA)是广泛血管内皮功能障碍的表现,是检测血管损伤的重要指标,也是心血管疾病的独立危险因素,对判断疾病发生、发展、预后有重要的参考价值。因此,研究OS患者中MA的改变及其与相关临床参数的相关性,对OS患者的预后判断可能有重要的临床意义。本文就OS患者中MA的改变及临床意义综述如下。The coexistence of chronic obstructive pulmonary disease （COPD） and obstructive sleep apnea hypopnea syndrome （OSAS） is called overlap syndrome （OS）. Compared to single COPD or OSAS patients, OS patients have more severe hypoxemia associated with nocturnal sleep, showing more severe im-pairment of lung function and pulmonary hypertension, and the prognosis is worse. It is of great clinical sig- nificance to improve the understanding of OS and to make the diagnosis and treatment timely of OS patients. Microalbuminuria （MA） is an important indicator of vascular endothelial dysfunction and an independent risk factor for cardiovascular disease. It has important reference value for judging the occurrence, develop- ment and prognosis of the disease. Therefore, to study the change of microalbuminuria and its correlation with clinical parameters in patients with OS may have important clinical significance on the prognosis of o- verlap syndrome patients. The changes and clinical significance of microalbuminuria in patients with overlap syndrome are summarized as follows.

关 键 词：肺疾病 慢性阻塞性/并发症 睡眠呼吸暂停 阻塞性/并发症 白蛋白尿 综述 

分 类 号：R563.9[医药卫生—呼吸系统] R766[医药卫生—内科学]