小剂量甲强龙治疗小儿支原体肺炎的疗效及其对患者血清TNF-α的影响  

Clinical effect of low-dose methylprednisolone in the treatment of mycoplasma pneumonia and its effect on serum TNF-α

作　　者：余洁明[1] 吴春远[1] 刘海英[1] 赵宏霞[1] YU Jie-ming;WU Chun-yuaa;LIU Hai-ying;ZHAO Hong-xia(Department of Pediatrics,Shenzhen Maternal and Child Health Care Hospital Affiliated to Southern Medical University,Shenzhen 518028,Guangdong,CHINA)

机构地区：[1]南方医科大学附属深圳市妇幼保健院儿科,广东深圳518028

出　　处：《海南医学》2018年第14期2039-2041,共3页Hainan Medical Journal

摘　　要：目的探讨小剂量甲强龙治疗小儿支原体肺炎的疗效及其对患者血清肿瘤坏死因子-α(TNF-α)的影响。方法选择2017年1~10月期间深圳市妇幼保健院儿科收治的86例小儿支原体肺炎为研究对象,根据随机数表法分为对照组和观察组,每组43例,对照组患儿予常规阿奇霉素序贯治疗,观察组联合应用小剂量甲强龙治疗,疗程7 d。比较两组患儿的临床疗效以及治疗前后的血清C反应蛋白(CRP)和TNF-α水平。结果观察组患儿的治疗总有效率为97.67%,明显高于对照组的86.05%,差异有统计学意义(P<0.05);治疗后,观察组患儿血清CRP、TNF-α分别为(6.75±2.93)mg/L、(14.87±4.45)ng/L,明显低于对照组的(9.27±3.06)mg/L、(18.79±5.13)ng/L,差异均有统计学意义(P<0.05)。结论小剂量甲强龙应用于小儿支原体肺炎的治疗可显著降低血清炎症因子水平,提高临床疗效。Objective To investigate the clinical effect of low-dose methylprednisolone in the treatment of mycoplasma pneumonia and its effect on serum tumor necrosis factor-α（TNF-α）. Methods During January 2017 to October 2017, 86 cases of mycoplasma pneumonia treated in Department of Pediatrics, Shenzhen Maternal and Child Health Care Hospital Affiliated to Southern Medical University were selected and divided into the observation group and control group according to random number method, with 43 cases in each group. The control group was treated with azithromycin sequential therapy, and the observation group received the treatment of azithromycin sequential therapy combined with low-dose methylprednisolone. The treatment course was seven days. The changes of serum C-reactive protein（CRP） and TNF-α were compared between the two groups before and after treatment. Results The total effective rate of the observation group was 97.67%, which was significantly higher than 86.05% in the control group（P〈0.05）; after the treatment, serum CRP and TNF-α in the observation group were respectively（6.75±2.93） mg/L and（14.87±4.45） ng/L,which were significantly lower than corresponding（9.27 ± 3.06） mg/L and（18.79 ± 5.13） ng/L in the control group（P〈0.05）. Conclusion The application of low-dose methylprednisolone for the treatment of mycoplasma pneumonia in children can significantly reduce serum levels of inflammatory factors and improve the clinical curative effect.

关 键 词：甲强龙 肺炎支原体 C反应蛋白 肿瘤坏死因子-α 疗效 

分 类 号：R725.6[医药卫生—儿科]