血清musclin水平与冠状动脉病变的关系  

Relationship between serum musclin concentrations and coronary artery disease

作　　者：冷晓旭 杨雪[1] 徐徐 季舒亚 韩俊 雷志均 李炳玉 刘班 车文良[1] 徐亚伟[1] 彭文辉[1] LENG Xiaoxu;YANG Xue;XU Xu;J I Shuya;HAN LI Bingyu;LIU Ban;CHE Wenliang;XU Yawei;Jun LEI;Zhijun;PENG Wenhui(Department of Cardiology,Tenth People＇s Hospital of Tongji University,Shanghai,200072,Chin)

机构地区：[1]同济大学附属上海市第十人民医院心内科,上海200072

出　　处：《临床心血管病杂志》2018年第7期648-651,共4页Journal of Clinical Cardiology

基　　金：国家自然科学基金资助项目(No:81670230)

摘　　要：目的:比较冠心病患者和对照组血清musclin水平,探讨musclin与冠心病的相关性。方法:纳入经冠状动脉造影确诊为冠心病的患者69例(冠心病组)和冠状动脉造影正常组96例(对照组),用ELISA方法测定其血清musclin水平。根据患者临床表现、心肌酶水平和心电图将冠心病组患者分为稳定型心绞痛组(30例)和急性冠脉综合征组(39例),同时根据冠状动脉病变支数将其分为单支组(27例)、双支组(22例)和多支组(20例)。比较各组血清musclin水平。结果:(1)与对照组比较,冠心病组血清musclin水平明显降低,差异有统计学意义[(119.64±87.57)pg/ml∶(82.03±56.21)pg/ml,P<0.01];(2)急性冠脉综合征组血清musclin水平较稳定型心绞痛组降低,差异有统计学意义[(72.69±28.65)pg/ml∶(94.17±77.86)pg/ml,P<0.05];(3)单支组[(69.99±22.28)pg/ml]、双支组[(82.52±60.00)pg/ml]和多支组[(97.73±78.64)pg/ml]血清musclin水平依次升高,但各组间差异无统计学意义。结论:冠心病患者血清musclin水平明显降低,且降低程度与冠心病严重程度呈负相关。Objective：To investigate the association between serum musclin level and coronary heart disease.Method：A total of 69 patients with angiographically proved coronary heart disease（CHD）and 96 control subjects without cardiovascular diseases were enrolled in this study.Serum musclin levels were assayed.Patients with CHD were divided into stable angina pectoris group（SAP group）and acute coronary syndrome group（ACS group）according to clinical manifestation,myocardial enzyme level and electrocardiogram.CHD patients were also simultaneous divided into single-branch,double-branch and multi-branch group according to the number of diseased vessels.Serum musclin levels were compared among these groups.Result：Compared with control group,CHD group had significant lower serum musclin level[（119.64±87.57）pg/ml∶（82.03±56.21）pg/ml,P〈0.01].Compared with SAP group,ACS group showed lower serum musclin level[（94.17±77.86）pg/ml∶（72.69±28.65）pg/ml,P〈0.05].The serum musclin level was increased gradually in single-branch [（9.99±22.28）pg/ml],double-branch[（82.52±60.00 pg/ml）]and multi-branch group [（97.73±78.64）pg/ml],respectively,but there was no statistical difference between each group.Conclusion：Decreased musclin serum levels are observed in patients with CHD,and negatively correlate with the severity of CHD.

关 键 词：冠心病 musclin 急性冠状动脉综合征 

分 类 号：R541.4[医药卫生—心血管疾病]