麻风病患者抑郁状态与生存质量关系的多重线性回归分析  

The multiple linear regression analysis on depression and quality of life of leprosy patients

作　　者：熊明洲 黎明[1,2] 王晓华 苏婷[1,2] 郑道城 杨斌[1,2] XIONG Ming-zhou, LIMing, WANG Xiao-hua, SU Ting, ZHENG Dao-cheng, YANG Bin(1. Leprosy Control Department, Dermatology Hospital of South Medical University, Guangzhou 510095, China; 2. Leprosy Control Department, Guang- dong Provincial Center for Skin Disease and ST1 Control, Guangzhou 510095, Chin)

机构地区：[1]南方医科大学皮肤病医院麻风病预防控制科,广东广州510095 [2]广东省皮肤性病防治中心麻风病预防控制科,广东广州510095

出　　处：《中华疾病控制杂志》2018年第7期700-702,707,共4页Chinese Journal of Disease Control & Prevention

基　　金：世界卫生组织贫穷传染病研究TDR/WPR联合小型资助项目(HQTDR1409931);南方医科大学科研启动计划青年科技人员培育项目(C1034402);广东省医学科学技术研究基金项目(A2017258)

摘　　要：目的分析麻风病患者抑郁状态与生存质量各维度间的相关关系。方法采用流行病调查用抑郁自评量表(center for epidemiologic studies depression scale,CES-D)和世界卫生组织生存质量简表(world health organization's quality of life questionnaire-brief version,WHOQOL-bref)对广东省麻风病患者进行抑郁程度和生存质量调查,用多重线性回归方法分析抑郁程度得分与生存质量各维度间的关系和强度。结果共263名麻风病患者完成了调查,其中男性177名(67.3%),女性86名(32.7%)。131名(49.8%)调查对象有抑郁症状,有抑郁症状调查对象生存质量各维度评分均低于无抑郁症状对象,差异均具有统计学意义(均有P<0.05)。在各维度中,生存质量总评、生理健康、心理健康、社会关系和环境因素得分与抑郁症状的回归系数分别为-0.340、-0.322、-0.644、-0.424和0.244,除生存质量总评外,其他回归系数差异均具有统计学意义(均有P<0.05)。结论广东省麻风病患者的抑郁症状发生率高,生存质量得分与CES-D得分有关联,应采用多层次的干预措施防止麻风病患者抑郁症的发生。Objective To analyze the correlativity of depression with the dimensions of quality off life （QOL） of leprosy patients. Methods The center epidemiological studies of depression scale （CES-D） and world health organization quality of life questionnaire-brief version （WHOQOL-bref） were used to assess the depression and QOL of leprosy patients in Guangdnng Province, and their correlativity was analyzed by the multiple linear regression analysis method. Results A total of 263 participants completed the survey, including 177 males （67.3%） and 86 females （32.7%）. Among them, 131 participants （49.8%） presented depression symptoms, and these people got significant lower scores in all the dimensions of QOL than people without depression symptom （all P〈0. 05）. The regression coefficients between depression and overall QOL, physical, psychological, social relationship and environment were -0. 340, -0. 322, -0. 644, -0. 424 and 0.244, respectively. All the regression coefficients got statistical significance （ all P〈0.05）, except overall QOL. Conclu- sions High depression symptom rate has been found in leprosy patients in Guangdong Province, the QOL scores have sisnificant correlatinns with CES-D score. Multilevel interventions should be taken to prevent the occurrence of depression among leprosy patients.

关 键 词：麻风病 抑郁 生存质量 多重线性回归 

分 类 号：R755[医药卫生—皮肤病学与性病学] R749.42[医药卫生—临床医学]