中年男性冠心病患者同型半胱氨酸与冠脉病变的相关性研究  

Correlation between homocysteine and coronary artery disease in middle-aged male patients with coronary heart disease

作　　者：张晋峰[1] 白春林[2] ZHANG Jinfeng;BAI Chunlin(Shanxi Medical University,Taiyuan 030001,China;The Second Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学,山西太原030001 [2]山西医科大学第二医院,山西太原030001

出　　处：《临床医药实践》2018年第8期570-572,共3页Proceeding of Clinical Medicine

摘　　要：目的:探讨中年男性冠心病患者血清同型半胱氨酸(Hcy)水平与冠脉病变程度的相关性。方法:选择2014年12月—2017年9月疑诊为冠心病的中年男性患者162例,年龄(50.2±9.5)岁;冠心病(CHD)患者126例,非冠心病患者36例(对照组)。冠心病患者根据冠脉狭窄程度分为轻度狭窄组、中度狭窄组、重度狭窄组,根据冠脉病变支数分为单支病变组、双支病变组、三支病变组。通过统计学方法分析中年男性冠心病患者Hcy水平与冠脉病变程度的相关性。结果:冠脉狭窄程度三组分别与对照组比较,差异有统计学意义(P<0.05),重度狭窄组与轻度狭窄组比较、轻度狭窄组与中度狭窄组比较、中度狭窄组与重度狭窄组比较,差异均具有统计学意义(P<0.05)。冠脉狭窄程度与Hcy水平呈正相关(r=0.596,P<0.01)。冠脉病变支数三组分别与对照组进行比较,差异均有统计学意义(P<0.05);三支病变组和单支病变组比较,差异有统计学意义(P<0.05);三支病变组与双支病变组比较、双支病变组和单支病变组比较差异无统计学意义(P>0.05)。冠脉病变支数与Hcy水平呈正相关(r=0.584,P<0.01)。结论:中年男性患者中血清同型半胱氨酸水平与冠脉病变程度呈正相关。Objective： To investigate the relationship between the level of serum homocysteine（ Hcy） and the severity of coronary artery disease in middle-aged men with coronary heart disease. Methods： Selected 162 cases of middle-aged men with suspected coronary heart disease in our hospital from December 2014 to September 2017,the average age is（ 50. 2 ± 9. 5）years old,there were 126 patients with coronary heart disease（ CHD） and 36 patients without coronary heart disease. Patients with coronary heart disease were divided into mild stenosis group,moderate stenosis group,and severe stenosis group according to the degree of coronary stenosis. According to the number of coronary lesions,the patients were divided into single-vessel disease group,double-vessel disease group,and three-vessel disease group. Statistical analysis was used to analyze the correlation between the level of Hcy and the degree of coronary artery disease in middle-aged men with coronary heart disease. Results： The degree of coronary stenosis was significantly different between the three groups and the control group（ P〈0. 05）.The difference between severe stenosis group and mild stenosis group,mild stenosis group and moderate stenosis group,moderate stenosis group and severe stenosis group were statistically significant（ P〈0. 05）. Coronary stenosis was positively correlated with the level of Hcy（ r = 0. 596,P〈0. 01）. The number of coronary lesions in the three groups was compared with the control group,and the differences were statistically significant（ P〈0. 05）,the difference between the three-vessel disease group and the single-vessel disease group was statistically significant（ P〈0. 05）. There was no significant difference between the three-vessel disease group and double-vessel disease group,double-vessel disease group and single-vessel disease group（ P〈0. 05）. The number of coronary lesions was positively correlated with the level of Hcy（ r = 0. 584,P〈0. 01）. Conclusion： The level of serum

关 键 词：中年男性 同型半胱氨酸 冠脉病变程度 

分 类 号：R541.4[医药卫生—心血管疾病]