血清胱抑素C与血浆B型利钠肽检测在高龄慢性心功能不全中的临床意义  

Clinical significance of serum cystatin C and plasma type B natriuretic peptide in elderly patients with chronic cardiac insufficiency

作　　者：钱俨[1] 陈锐[1] QIAN Yan;CHEN Rui(Department of Geriatrics,Shanghai Eighth People′s Hospital,Shanghai 200235,Chin)

机构地区：[1]上海市第八人民医院老年科,上海200235

出　　处：《国际检验医学杂志》2018年第A01期81-85,共5页International Journal of Laboratory Medicine

摘　　要：目的 研究血清胱抑素C与血浆B型利钠肽检测在高龄慢性心功能不全中的临床意义。 方法 选取2014年2月至2017年2月，于该院接受治疗的高龄慢性心功能不全患者227例为研究对象。根据纽约心脏协会心功能（NYHA）分级标准将其分为心功能Ⅱ级组、心功能Ⅲ级组以及心功能Ⅳ级组。分别比较3组人员的性别、年龄、体质量、身高、尿素氮以及肌酐水平，同时采用免疫比浊法检测血清胱抑素C水平，采用免疫荧光法检测血浆B型利钠肽水平，采用心脏彩超检测左室射血分数水平。分析高龄慢性心功能不全患者病情严重程度与左室射血分数、血清胱抑素C以及血浆B型利钠肽水平的相关性。 结果 3组人员性别、年龄、体重、身高、尿素氮以及肌酐水平对比均不明显，各组间对比无统计学意义（均 P ＞0.05）。心功能Ⅱ级、心功能Ⅲ级以及心功能Ⅳ级的血清胱抑素C以及血浆B型利钠肽水平均呈逐渐上升趋势，且各组间对比差异有统计学意义（均 P ＜0.05）；而左室射血分数水平成逐渐下降趋势，且各组间对比差异有统计学意义（均 P ＜0.05）。经SPearman相关性分析可得：高龄慢性心功能不全患者NYHA分级左室射血分数呈负相关（ P ＜0.05），与血清胱抑素C、血浆B型利钠肽水平均呈正相关（ P ＜0.05）。 结论 血清胱抑素CC与血浆B型利钠肽联合检测应用于高龄慢性心功能不全的诊断中，可有效反映患者病情严重程度。Objective ： To investigate the clinical significance of serum cystatin C and plasma type B natriuretic peptide in elderly patients with chronic cardiac insufficiency. Methods ： From February 2014 to February 2017,the elderly chronic heart failure treated in our hospital of 227 cases was as the research object.According to the New York Heart Association （NYHA） classification standard was divided into heart function grade Ⅱ and grade Ⅲ group,cardiac function and heart function class Ⅳ group.The three groups were compared with the gender,age,weight,height,blood urea nitrogen,creatinine,and serum cystatin levels,while using immune serum cystatin C levels of turbidity,detection of the level of plasma B type natriuretic peptide by immunofluorescence,the cardiac ultrasound detection of left ventricular ejection fraction.Analysis of elderly patients with chronic heart failure with the severity of left ventricular ejection fraction,the relationship between serum cystatin C and plasma B type natriuretic peptide levels. Results： The three groups of gender,age,weight,height,blood urea nitrogen and creatinine levels were compared between groups were not obvious,which was not statistically significant（ P 〉0.05）.The cardiac function class II,cardiac function class III and cardiac function class IV serum cystatin C and plasma B type natriuretic peptide levels showed a gradual upward trend,and the difference between the groups was statistically significant（ P 〈0.05）;and the left ventricular ejection fraction level decreased gradually,the comparison was statistically significant between the groups （ P 〈0.05）.By Spearman correlation analysis：elderly patients with chronic heart failure NYHA was a negative correlation between left ventricular ejection fraction grading （ P 〈0.05）,and serum cystatin C,plasma B type natriuretic peptide levels were positively correlated （ P 〈0.05）. Conclusion ： The combined detection of serum cystatin C and plasma type B natriuretic peptide in the diagno

关 键 词：慢性心功能不全 高龄 血清胱抑素C 血浆B型利钠肽 左室射血分数 

分 类 号：R541[医药卫生—心血管疾病]