非淋菌性尿道炎患者支原体感染及耐药性分析  

Analysis on mycoplasma culture and drug susceptibility testing results for patients with non-gonococcal urethritis

作　　者：许娜娜[1] 许素彦 马景[1] 董志玲[1] 牛丽辉[1] 李晓燕[1] XU Nana;XU Suyan;MA Jing;DONG Zhiling;NIU Lihui;LI Xiaoyan(Department of Clinical Laboratory,Handan Central Hospital,Handan,Hebei 056001,China;Emergency Department,Affiliated Hospital of Hebei University of Engineering,Handan,Hebei 056002,China)

机构地区：[1]邯郸市中心医院检验科,河北邯郸056001 [2]河北工程大学附属医院急诊科,河北邯郸056002

出　　处：《国际检验医学杂志》2018年第A01期101-103,共3页International Journal of Laboratory Medicine

摘　　要：目的 探讨非淋菌性尿道炎患者的支原体感染情况及其耐药性，以指导临床合理用药，提高疗效。 方法 采用回顾性研究的方法，对该院2016年1~12月疑似非淋菌性尿道炎患者送检的各类标本中分离出的支原体用解脲支原体和人型支原体选择分离培养鉴定和药敏试剂盒对其进行培养、鉴定、计数及药敏试验。 结果 377例标本中，共检出支原体179例，检出率为47.48%。解脲脲原体（Uu）、人型支原体（Mh）和Uu联合Mh的阳性率分别为37.40%（141例）、1.33%（5例）和8.75%（33例）。其中男性支原体培养阳性率为 15.79% ，女性支原体培养阳性率为53.13%，女性明显高于男性（ P 〈0.05）。Uu对抗菌药物的敏感率分别为强力菌素（95.04%）、米诺环素（95.00%）、克拉霉素（84.78%）、交沙霉素（73.05%）等。Uu对诺氟沙星（ 97.26 %）、氧氟沙星（84.29%）和环丙沙星（82.48%）保持较高的耐药率。 结论 在支原体导致的非淋菌性尿道炎中，主要由Uu引起，女性感染率高于男性，临床治疗推荐选用强力菌素、米诺环素、克拉霉素和交沙霉素。Objective： To study the drug resistance of mycoplasma infections in the patients with non-gonococcal urethritis（NGU）,and provide instructions for the clinical treatment and reasonable use of antibiotics. Methods： A retrospective analysis of the mycoplasma isolated from various specimens of patients with non-gonococcal urethritis（NGU） from Jan.2016 to Dec.2016 was performed,Comercial kit was used for culture,identification,counting,and susceptibility testing of Mycoplasma strains. Results： Mycoplasma was identified in （47.48%）of the specimens.Ureaplasm urealyticum （Uu） alone,Mycoplasma hominis （Mh）alone and Uu plus Mh mixed infection were found in （37.40%）,（1.33%）,and （8.75%）cases,respectively.The prevalence of mycoplasma in male was 15.79%,in female was 53.13%,the positive rate of the female was much higher than that of the male（ P 〈0.05）.Susceptibility testing of Ureaplasm urealyticum（Uu） showed that these strains were highly susceptible to doxycycline （95.04%）,minocycline（95.00%）,Clarithromycin（84.78%）and josamycin（73.05%）,were highly resistant to norfloxacin（97.26%）,ofloxacin（84.29%） and ciprofloxacin（ 82.48 %）. Conclusion ： The nongonococcal urethritis caused by mycoplasma is predominantly due to Uu,especially in young and mid-aged women.Doxycycline,minocycline,clarithromycin and josamycin are the primary choices for urogenital mycoplasma infection.

关 键 词：泌尿生殖道 支原体 非淋菌性尿道炎 药敏试验 

分 类 号：R696[医药卫生—泌尿科学]