骨形态发生蛋白2纳米人工骨配合中医整脊手法治疗特发性脊柱侧弯的影像学变化  

Imaging changes of idiopathic scoliosis treated with bone morphogenetic protein 2 nanometer artificial bone implantation combined with chiropractic manipulation

作　　者：李连泰[1] 胡华[1] 王书君[1] 谢双喜[1] 王君博 王立新 Li Lian-tai;Hu Hua;Wang Shu-jun;Xie Shuang-xi;Wang Jun-bo;Wang Li-xin(Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei Province,China;Traditional Chinese Medicine Hospital of Chengde County,Chengde 067400,Hebei Province,China)

机构地区：[1]承德医学院附属医院,河北省承德市067000 [2]承德县中医院,河北省承德市067400

出　　处：《中国组织工程研究》2018年第26期4139-4143,共5页Chinese Journal of Tissue Engineering Research

基　　金：河北省中医药管理局指令性课题(2016067)

摘　　要：背景:近年来,整脊手法配合骨形态发生蛋白2纳米人工骨在特发性脊柱侧弯患者中得到应用,且效果理想,但该结论有待验证。目的:探讨整脊手法配合骨形态发生蛋白2纳米人工骨在特发性脊柱侧弯患者中的应用效果及影像学特点。方法:将80例年龄9-16岁的儿童特发性脊柱侧弯患者分2组治疗,对照组(n=40)进行整脊手法治疗,治疗组(n=40)在整脊手法治疗基础上进行骨形态发生蛋白2纳米人工骨植入治疗,整脊手法治疗每2 d一次。治疗后3个月,采用X射线评估两组脊柱侧弯Cobb角,采用目测类比评分评估疼痛情况。结果与结论:(1)两组治疗后3个月的目测类比评分、脊柱侧弯Cobb角均较低于治疗前(P<0.05);(2)治疗组治疗后3个月的疗效率高于对照组(90%,73%,P<0.05),治疗后3个月的腰椎及胸椎Cobb角明显低于对照组[胸椎:(17.32±3.98)°,(19.27±4.23)°;腰椎:(18.21±3.12)°,(23.25±4.64)°,P<0.05],治疗后1,2,3个月的目测类比评分明显低于对照组[治疗组:(3.51±1.02),(1.15±0.57),(0.99±0.12)分;对照组:(5.01±1.31),(3.57±0.95),(1.46±0.64)分,P<0.05];(3)结果表明,整脊手法配合骨形态发生蛋白2纳米人工骨治疗特发性脊柱侧弯能改善患者脊柱功能,缓解患者疼痛。BACKGROUND： In recent years, chiropractic manipulation with bone morphogenetic protein 2 nanometer artificial bone has achieved ideal outcomes in idiopathic scoliosis patients. However, this conclusion needs to be further verified. OBJECTIVE： To investigate the effect and imaging features of chiropractic manipulation combined with bone morphogenetic protein 2 nanometer artificial bone implantation in patients with idiopathic scoliosis. METHODS： Eighty Idiopathic scoliosis children aged 9-16 years were divided into two groups. The control group （n=40） was treated with chiropractic manipulation. The treatment group （n=40） was treated with chiropractic manipulation combined with bone morphogenesis protein 2 nanometer artificial bone implantation. Chiropractic treatment was performed once every other day. Three months after treatment, X-ray was used to assess the Cobb angle of scoliosis and visual analogue scale was used to evaluate the pain. RESULTS AND CONCLUSION： （1） The visual analogue scale score and the Cobb angle of scoliosis were lower in both groups at 3 months after treatment than the baseline （P 〈 0.05）. （2） At 3 months after treatment, the curative effect of treatment group was higher than that of control group （90% vs. 73 %, P 〈 0.05）. The Cobb angles of the lumbar and thoracic vertebrae in the treatment group at 3 months after treatment were significantly lower than those of the control group [thoracic vertebrae （17.32±3.98）° vs. （19.27±4.23）°; lumbar vertebrae （18.21±3.12）° vs. （23.25±4.64）°, P 〈 0.05]. The visual analogue scale scores in the treatment group were significantly lower than those in thecontrol group at 1, 2 and 3 months after treatment [treatment group （3.51±1.02）, （1.15±0.57）, （0.99±0.12） points; control group （5.01±1.31）, （3.57±0.95） and （1.46±0.64） points, respectively; P 〈 0.05]. These findings suggest that the bone morphogenetic protein 2 nanometer artificial bone implantation combined with

关 键 词：骨形态发生蛋白2纳米人工骨 特发性脊柱侧弯 整脊手法 应用效果 影像学特点 生物材料 Cobb角 直观模拟量表 脊柱功能 生物材料 

分 类 号：R318[医药卫生—生物医学工程]