糖肾方联合氯沙坦钾对糖尿病肾病患者血清炎症因子的影响研究  

Influence research of Tangshen formula combined with Losartan Potassium on serum inflammatory factors in patients with diabetic nephropathy

作　　者：张敏 林碧莹 张相宏 李婉雯 ZHANG Min;LIN Bi-ying;ZHANG Xiang-hong(Guangdong Hospital of lntegrated Traditional Chinese and Western Medicine,Guangzhou 528200,Chin)

机构地区：[1]广东省中西医结合医院,528200

出　　处：《中国实用医药》2018年第20期104-106,共3页China Practical Medicine

基　　金：广东省中医药局基金(项目编号:20142022)

摘　　要：目的探讨糖肾方联合氯沙坦钾对糖尿病肾病患者血清炎症因子的影响。方法 78例糖尿病肾病患者,随机分为对照组和观察组,各39例。对照组给予氯沙坦钾治疗,观察组在对照组基础上给予糖肾方治疗,比较两组临床疗效和血清炎症因子[肿瘤坏死因子(TNF-α)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平。结果观察组总有效率92.31%高于对照组的74.36%,差异有统计学意义(P<0.05)。两组治疗前TNF-α、CRP及IL-6水平比较,差异无统计学意义(P>0.05);治疗后观察组TNF-α、CRP及IL-6水平均低于对照组,差异有统计学意义(P<0.05)。结论糖肾方联合氯沙坦钾治疗糖尿病肾病患者疗效显著,并能有效降低血清炎症因子水平,从而有效延缓疾病进程,改善患者预后,值得临床推广使用。Objective To investigate the effect of Tangshen formula combined with Losartan Potassium on serum inflammatory factors in patients with diabetic nephropathy.Methods A total of 78 patients with diabetic nephropathy were randomly divided into the control group and the observation group,39 cases in each group.The control group was treated with Losartan Potassium,the observation group was treated with Tangshen formula on the basis of the control group.The clinical efficacy and levels of serum inflammatory factors [Tumor necrosis factor（TNF-α）,C reactive protein（CRP） and interleukin-6（IL-6）] were compared between the two groups.Results The total effective rate of observation group was 92.31%,which was significantly higher than 74.36% of the control group,the difference was statistically significant（P〈0. 05）.There was no statistically significant differences in TNF-α,CRP and IL-6 between the two groups（P〈0. 05）.The levels of TNF-α,CRP and IL-6 in the observation group were significantly lower than those of the control group,the differences were statistically significant（P〈0. 05）.Conclusion The curative effect of Tangshen formula combined with Losartan Potassium in the treatment of patients with diabetic nephropathy is distinct,and can effectively reduce the level of serum inflammatory factors,thus effectively postpone the disease process and improve the prognosis of patients.It is worthy of clinical application.

关 键 词：糖肾方 氯沙坦钾 糖尿病肾病 炎症因子 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]