Structure and Function of TPC1 Vacuole SV Channel Gains Shape  

作　　者：Rainer Hedrich Thomas D. Mueller Dirk Becker Irene Marten 

机构地区：[1]Institute for Molecular Plant Physiology and Biophysics, University of Wurzburg, Julius-yon-Sachs Platz 2, 97082 Wurzburg, Germany

出　　处：《Molecular Plant》2018年第6期764-775,共12页分子植物（英文版）

摘　　要：Plants and animals in endosomes operate TPCI/SV-type cation channels. All plants harbor at least one TPC1 gene. Although the encoded SV channel was firstly discovered in the plant vacuole membrane two decades ago, its biological function has remained enigmatic. Recently, the structure of a plant TPC1/SV channel protein was determined. Insights into the 3D topology has now guided site-directed mutation ap- proaches, enabling structure-function analyses of TPC1/SV channels to shed new light on earlier findings. Fou2 plants carrying a hyperactive mutant form of TPC1 develop wounding stress phenotypes. Recent studies with fou2 and mutants that lack functional TPC1 have revealed atypical features in local and long-distance stress signaling, providing new access to the previously mysterious biology of this vacuolar cation channel type in planta.Plants and animals in endosomes operate TPCI/SV-type cation channels. All plants harbor at least one TPC1 gene. Although the encoded SV channel was firstly discovered in the plant vacuole membrane two decades ago, its biological function has remained enigmatic. Recently, the structure of a plant TPC1/SV channel protein was determined. Insights into the 3D topology has now guided site-directed mutation ap- proaches, enabling structure-function analyses of TPC1/SV channels to shed new light on earlier findings. Fou2 plants carrying a hyperactive mutant form of TPC1 develop wounding stress phenotypes. Recent studies with fou2 and mutants that lack functional TPC1 have revealed atypical features in local and long-distance stress signaling, providing new access to the previously mysterious biology of this vacuolar cation channel type in planta.

关 键 词：Ca^2＋ sensors TPC1/SV channel vacuole membrane voltage voltage sensor 

分 类 号：Q51[生物学—生物化学] S511.01[农业科学—作物学]