25羟维生素D和降钙素原在妊高症孕妇体内的表达及临床意义研究  

Expression and Clinical Significance of 25 Hydroxy Vitamin D and Procalcitonin in Pregnant Women with Pregnancy-induced Hypertension

作　　者：王霞[1] 李庆[1] 麦燕[1] 陈玉蓉[1] 钱沁佳[1] 陈雪莲[1] WANG Xia;LI Qing;MAI Yan;CHEN Yu- rong;QIAN Qin-jia;CHEN Xue- lian(Department of Obstetrics and Gynecology,the Third People＇s Hospital of Hainan Province,Sanya 572000,Chin)

机构地区：[1]海南省第三人民医院妇产科,海南三亚572000

出　　处：《标记免疫分析与临床》2018年第7期1041-1043,1047,共4页Labeled Immunoassays and Clinical Medicine

摘　　要：目的检测正常孕妇和妊高症孕妇不同孕周的血清25羟维生素D和降钙素原的表达及临床意义。方法选择152例于2015年12月至2016年12月在本院定期做产检并最终发展为妊娠期高血压疾病的孕妇作为本次研究的对象,将其从早孕时期的检查报告整理建档。其中52人发展为妊娠期高血压作为A组,58人发展为轻度子痫前期划为B组,42人发展为重度子痫前期作为C组,并随机抽查同期检查的96例正常孕妇作为对照组,采用电化学发光免疫分析法检测孕妇在妊娠早孕、中孕和晚孕时血清25羟维生素D和降钙素原PCT水平并进行回顾性研究,比较各组各阶段血清25羟维生素D及降钙素原PCT水平。结果早孕期,妊娠期高血压疾病组与正常妊娠组的孕妇体内25羟维生素D和降钙素原PCT的水平无显著差异,P>0.05;中孕和晚孕期,妊娠期高血压组与正常妊娠组的孕妇体内25羟维生素D和降钙素原PCT的水平比较差异均有统计学意义(P<0.05),并且随着妊娠期高血压疾病的病情逐渐加重,25羟维生素D和PCT水平呈下降趋势。结论血清25羟维生素D和降钙素原PCT在妊高症患者中水平均下降,且妊高症高血压>轻度子痫前期>重度子痫前期,说明随着妊娠期高血压病情的加重,血清25羟维生素D水平与降钙素原PCT水平逐渐降低,因此其妊娠期水平与妊高症的发展有着密切关系,定期监测孕妇体内的25羟维生素D水平与降钙素原PCT水平有助于临床的病情诊断。Objective To investigate the expression and clinical significance of serum 25 hydroxy vitamin D and procalcitonin in normal pregnant women and pregnancy-induced hypertension（PIH）. Methods We selected 152 pregnant women from December 2015 to December 2016 in our hospital for routine prenatal examinations and then developed pregnancy-induced hypertension disease. The establishment of disease during pregnancy is less than 12 weeks. The development of hypertension in pregnancy were 52 as group A,and 58 people with mild preeclampsia as group B,while severe preeclampsia were 42 as group C. 96 cases of normal pregnant women during the same period were randomly selected as the control group. By electro chemiluminescence immunoassay,the serum 25 hydroxyvitamin D and procalcitonin levels of PCT were detected and analyzed retrospectively in two groups of pregnant women for pregnancy,pregnancy and late pregnancy,then compared the serum 25 hydroxyvitamin D and procalcitonin level PCT. Results For the results of the first trimester,there was no significant difference in pregnant women for 25 hydroxyvitamin D and calcitonin in pregnancy-induced hypertension and normal pregnancy group in the original PCT level（P〈0. 05）; while in the middle and late pregnancy,the level of 25 hydroxyvitamin D and calcitonin in pregnancy-induced hypertension and normal pregnancy group were significantly different（P〈0. 05）,and with hypertensive disorder complicating pregnancy condition gradually worsened,and 25 hydroxyvitamin D and PCT levels decreased. Conclusion The serum 25 hydroxyvitamin D and procalcitonin in patients with hypertensive disorders in pregnancy were decreased,and the decreased incidence of preeclampsia and serum25 hydroxyvitamin D levels of correlation appeared earlier in preeclampsia clinical symptoms. Procalcitonin levels were also associated with preeclampsia,and the more severe the disease,the lower the procalcitonin level is.

关 键 词：25羟维生素D 降钙素原PCT 妊高症孕妇 

分 类 号：R714.246[医药卫生—妇产科学]