基于阻抗检测微传感技术的皮肤渗透性评估方法  

Evaluation of Skin Permeability Based on Impedance Detection by Microsensor Technology

作　　者：赵湛[1,2] 卢飞 王辰硕[1,2] 赵荣建 杜利东 方震[1,2] ZHAO Zhan;LU Fei;WANG Chenshuo;ZHAO Rongjian;DU Lidong;FANG Zhene(Institute of Electronics,Chinese Academy of Sciences,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院电子学研究所,北京100190 [2]中国科学院大学,北京100049

出　　处：《电子与信息学报》2018年第8期1927-1933,共7页Journal of Electronics & Information Technology

基　　金：国家自然科学基金(61431019);北京市自然科学基金(Z160002)~~

摘　　要：基于宏电极的单频皮肤阻抗测量是利用阻抗进行皮肤渗透性研究的传统方法之一,其存在误差大、灵敏度低且不易于设备集成的缺点。由此,该文通过分析皮肤的分层生理结构以及皮肤渗透性与角质层(SC)阻抗的关系,设计了基于柔性非对称叉指微电极的皮肤阻抗传感器,构建了RCW分层阻抗模型,实现了对人体角质层阻抗的检测分析。实验结果表明,传感器输出的阻抗模值msdZ(100)和scR模型拟合参数可用作表征皮肤渗透性的重要指标。该方法可用于区分不同个体的皮肤渗透性,为人体生理生化检测相关的可穿戴设备参数调节提供依据。Traditionally, skin permeability evaluation, which is realized by impedance detected at a certain frequency based on macro electrodes, has the disadvantages of large measurement error, low sensitivity and difficulty in integration. In order to resolve this problem, a flexible non-symmetric interdigital microsensor is designed by analyzing the layered structure of skin and the relationship between skin permeability and impedance of Stratum Corneum（SC）. The impedance of SC is measured and analyzed based on the RCW-layered impedance model. It is illustrated that the impedance magnitude ｜Zmsd（100）｜ of microsensor output and model fitting parameters Rsc can be used as the important indicators to evaluate skin permeability. It is proved that the developed sensor can be applied to distinguishing the different individuals＇ skin permeability, and it strongly supports the adjustment of wearable devices related to human physiological and biochemical detection.

关 键 词：可穿戴设备 皮肤阻抗 叉指微电极 皮肤渗透能力 阻抗模型 

分 类 号：TP212.3[自动化与计算机技术—检测技术与自动化装置]