大黄液灌肠治疗新生儿高胆红素血症临床研究  

A clinical study of rhubarb liquid enema in the treatment of neonatal hyperbilirubinemia

作　　者：张旭铭[1] 张小飞[1] 王春艳[1] 潘志尧 刘孝英 刘旭和 谯明燕 牛春[2] ZHANG Xu-ming;ZHANG Xiao-fei;WANG Chun-yan(Children＇s Medical Foundation NICU,Dazhou Hospital of Integrated Traditional and West-ern Medicine,Dazhou,Sichuan 635000,Chin)

机构地区：[1]四川省达州市中西医结合医院儿童医健基金会新生儿重症监护室,635000 [2]四川省达州市妇幼保健院,635000

出　　处：《临床合理用药杂志》2018年第20期18-20,共3页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察大黄液灌肠治疗新生儿高胆红素血症的临床疗效。方法将科室收治的新生儿高胆红素血症患儿100例随机分为对照组和观察组,每组50例。2组均给予相同的基本治疗,达到光疗标准的采用蓝光光疗。观察组在以上治疗基础上每天加用大黄煎液滴注灌肠治疗,每天2次,连用7 d。观察比较2组治疗前后血清胆红素水平及治疗后黄疸消退情况;比较2组治疗7 d后临床疗效;观察治疗期间2组不良反应发生情况。结果治疗48 h、72 h、7 d后,2组血清TBi L水平较治疗前均降低(P<0.01);治疗72 h、7 d后,观察组TBi L水平低于对照组(P<0.01),提示观察组血清TBi L消退较对照组更快。观察组总有效率为98.0%,高于对照组的86.0%(P<0.05)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论大黄液灌肠治疗新生儿高胆红素血症效果较显著,无明显不良反应,值得临床推广应用。Objective To observe the clinical efficacy of Rhubarb decoction enema in the treatment of neonatal hyperbilirubinemia. Methods 100 neonates with hyperbilirubinemia were randomly divided into control group and observation group,50 cases in each group. The 2 groups were treated with basic treatment. The observation group was additionally treated with Rhubarb decoction enema. The clinical efficacy and adverse reactions of the 2 groups were compared. Serum bilirubin levels and jaundice subsiding were compared between the 2 groups before and after treatment. Results The total effective rate of the observation group was 98. 0%,which was higher than that of the control group（ 86. 0%）（ P〈0. 05）,and there was no significant difference in the incidence of adverse reactions between the 2 groups（ P〈0. 05）. The level of serum TBi L of48 h,72 h and 7 d in the 2 groups was lower than that before treatment（ P〈0. 01）,and the level of TBi L in the observation group was lower than that of the control group（ P〈0. 01） in the treatment of 72 h and 7 d,suggesting that the serum TBi L decline of the observation group was faster than that of the control group. Conclusion Rhubarb decoction enema for neonatal hyperbilirubinemia,the effect is significant,no obvious adverse reactions,worthy of clinical application.

关 键 词：新生 婴儿 高胆红素血症 大黄液 灌肠 

分 类 号：R272[医药卫生—中医儿科学]