老年高血压患者血浆同型半胱氨酸及超敏C反应蛋白水平与颈动脉粥样硬化的相关性  

Correlation between plasma homocysteine,high sensitivity C reactive protein and carotid atherosclerosis in elderly hypertensive patients

作　　者：陈桂青[1] 王石林[1] 陈树丹[1] 邱向艳 房贤聪 江晓林 Chen Guiqing;Wang Shilin;Chen Shudan;Qiu Xiangyan;Fang Xiancong;Jiang Xiaolin(Department of Geriatrics,Huizhou Central people＇s Hospital,Huizhou 516001,China)

机构地区：[1]广东惠州市中心人民医院老年病区,516001 [2]广东惠州市第一人民医院检验科

出　　处：《中国临床保健杂志》2018年第3期353-356,共4页Chinese Journal of Clinical Healthcare

基　　金：广东省惠州市科技计划项目(2014Y020)

摘　　要：目的探讨老年高血压患者血浆同型半胱氨酸(Hcy)及超敏C反应蛋白(hs-CRP)水平与颈动脉粥样硬化的相关性。方法选取167例老年高血压患者作为研究组,另选择同期体检的36例健康者作为对照组,检测血压、Hcy、hs-CRP及颈动脉粥样硬化。按照1999年中国高血压防治指南标准将研究组患者分为高血压1级组(n=41)、高血压2级组(n=64)、高血压3级组(n=62)。根据颈动脉粥样硬化的超声结果,将老年高血压患者分为颈动脉颈动脉内膜中层厚度(IMT)正常组(n=40)、颈动脉IMT增厚组(n=62)、颈动脉斑块形成组(n=65),并根据颈动脉粥样硬化的程度进行分级(0~4级)。结果老年高血压患者的Hcy和hs-CRP水平明显高于对照组(P<0.05);高血压2级组和高血压3级组患者的Hcy和hs-CRP水平均显著高于高血压1级组(P<0.05),高血压3级组患者的Hcy和hs-CRP水平均显著高于高血压2级组(P<0.05);颈动脉IMT增厚组和颈动脉斑块形成组患者的Hcy和hs-CRP水平均显著高于颈动脉IMT正常组(P<0.05),颈动脉斑块形成组患者的Hcy和hs-CRP水平均显著高于颈动脉IMT增厚组(P<0.05);颈动脉粥样硬化分级越高,患者的Hcy和hs-CRP水平越高。结论老年高血压患者的血压越高,血浆Hcy、hs-CRP水平越高,颈动脉粥样硬化程度越重,这提示Hcy及hs-CRP升高可能是颈动脉粥样硬化的危险因素。Objective To investigate the relationship between plasma homocysteine（Hcy）,high-sensitivity C-reactive protein （hs-CRP） levels and carotid atherosclerosis in elderly patients with essential hypertension. Methods 167 cases of elderly hypertensive patients were selected as the study group.Another 36 healthy subjects who were checked up in our hospital during the same period were selected as the control group.Blood pressure,plasma Hcy, hs-CRP and carotid atherosclerosis were checked.Patients in the study group were divided into hypertension grade 1 group（ n =41）,hypertension grade 2 group （ n =64） and hypertension grade 3 group（ n =62） according to the guidelines for prevention and treatment of hypertension in China in 1999.According to the results of carotid atherosclerosis,the elderly hypertensive patients were divided into normal carotid artery IMT group（ n =40）,carotid IMT thickening group（ n =62）,neck Arterial plaque formation（ n =65） and was graded basis on the degree of carotid atherosclerosis （grades 0-4）. Results The levels of plasma Hcy and hs-CRP in elderly hypertensive patients were significantly higher than those in control group （ P〈0.05 ）.The levels of plasma Hcy and hs-CRP in hypertension grade 2 and 3 were significantly higher than those in hypertension grade 1（ P〈0.05 ）.The levels of plasma Hcy and hs-CRP in hypertension grade 3 patients were significantly higher than those in hypertension grade 2 patients （ P〈0.05 ）.In the carotid IMT thickening patients and carotid artery plaque patients,Hcy and hs-CRP levels were significantly higher than those of carotid IMT normal group（ P〈0.05 ）.The levels of Hcy and hs-CRP in carotid plaque group were significantly higher than those in carotid IMT group （ P〈0.05 ）;the degree of carotid atherosclerosis was positively correlated with the level of plasma Hcy and hs-CRP in patients. Conclusion The higher the blood pressure in elderly patients,the higher the level of plasma Hcy and hs-CRP and t

关 键 词：高血压 高半胱氨酸 C反应蛋白质 动脉粥样硬化 老年人 

分 类 号：R544.1[医药卫生—心血管疾病]