替格瑞洛对行冠状动脉介入治疗患者的疗效及安全性分析  

Analysis of efficacy and safety of ticagrelor and clopidogrel on platelet inhibition in patients after PCI

作　　者：刘丽媚[1] 李雪锋[1] 李存仁[1] LIU Li-mei;LI Xun-jeng;LI Cun-ren(Cardiovascular Department,The People＇s Hospital of Meizhou City,Meizhou 514031,China)

机构地区：[1]梅州市人民医院心血管内一科,广东梅州514031

出　　处：《吉林医学》2018年第6期1093-1095,共3页Jilin Medical Journal

摘　　要：目的:观察PCI术后患者使用替格瑞洛与氯吡格雷对血小板抑制的效果,比较两种药物的临床疗效。方法:入选156例PCI术后患者,随机分为替格瑞洛组79例和氯吡格雷组77例,分别给予替格瑞洛加阿司匹林,氯吡格雷加阿司匹林治疗,术后第24小时及术后1个月后对所有患者测定血小板抑制率,对两组患者术后1个月后主要不良心血管事件(MACE)、出血事件等相关指标进行比较。结果:术后第24小时及术后1个月替格瑞洛组患者血小板抑制率均高于氯吡格雷组(P<0.05)。术后1个月两组患者MACE发生率、出血事件发生率比较差异均无统计学意义(均P>0.05)。结论:PCI术后患者使用替格瑞洛抑制血小板聚集作用优于氯吡格雷,不增加出血风险。Objective To explore effect of ticagrelor and clopidogrel on platelet inhibition in patients after PCI,and to compare the clinical efficacy of the two drugs. Method A total of 156 patients after PCI were randomly divided into 2 groups,ticagrelor group,the patients received ticagrelor with aspirin,n = 79 and clopidogrel group,the patients received clopidogrel with aspirin,n = 77. The platelet inhibition rate of all the patients were determined 24 hours later after operation and after 1 month. The major adverse cardiac events（ MACE） and bleeding events result were compared between 2 groups after 1 month. Results Compared with clopidogrel group,the platelet inhibition rate was higher in ticagrelor group 24 hours later after operation and after 1 month（ P〈0.05）,there was no obvious difference in incidence of MACE and bleeding events of ticagrelor group after 1 month（ P〉0.05）. Conclusion In patients after PCI,ticagrelor could inhibit platelet aggregation better than clopidogrel,and would not increase the risk of bleeding.

关 键 词：替格瑞洛 氯吡格雷 经皮冠状动脉介入治疗 抗血小板治疗 

分 类 号：R541.4[医药卫生—心血管疾病]