常山口服液抗鸡柔嫩艾美耳球虫广东分离株的疗效研究  

Curative Efficacy of Radix Dichroa Oral Liquid on Coccidiosis Induced by E. tenella Isolated from Guangdong in Chickens

作　　者：王玲[1] 郭志廷[1] 龚振兴[2] 蔡建平[2] 杨峰[1] WANG Ling;GUO Zhi-ting;GONG Zhen-xing;CAI Jian-ping;YANG Feng(Key Laboratory of New Animal Drug Project,Gansu Province Key Laboratory of Veterinary Pharmaceutics Discovery,Ministry of Agriculture Lanzhou Institute of Animal Science and Veterinary Pharmaceutics,Chinese Academy of Agricultural Sc（CAAS）,Lanzhou730050,China;State Key Laboratory of Veterinary Etiological Biology,Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China)

机构地区：[1]中国农业科学院兰州畜牧与兽药研究所,农业部兽用药物创制重点实验室,甘肃兰州730050 [2]中国农业科学院兰州兽医研究所,家畜疫病病原生物学国家重点实验室,甘肃兰州730046

出　　处：《中国兽药杂志》2018年第6期46-51,共6页Chinese Journal of Veterinary Drug

基　　金：中央级公益性科研院所专项资金项目(1610322017018);甘肃省科技支撑计划(1604NKCA069-01)

摘　　要：研究旨在明确常山口服液治疗鸡球虫病的疗效和最佳给药剂量。试验选取90只14日龄健康雏鸡,随机分为9组,每组10只,即常山口服液组(分别为2.5、5.0、15.0、25.0、35.0、50.0 m L/L水剂量)、妥曲珠利组(1 m L/L水)、感染对照组和健康对照组。除健康对照组外,每只鸡接种7×104个柔嫩艾美耳球虫广东分离株的孢子化卵囊,饮水给药7 d,观察其疗效。结果显示,常山口服液各剂量组其盲肠和十二指肠的肿胀现象较感染对照组明显减轻,血液性内容物明显减少,抗球虫指数(ACI)分别为87.7、136.2、141.8、136.2、109.7和108.0,均高于感染对照组;常山口服液按5.0、15.0及25.0 m L/L水剂量给药,抗球虫指数均高于对照药物妥曲珠利组(ACI=124.8)。结果表明,人工感染条件下,常山口服液较化学药物妥曲珠利具有更好的抗球虫疗效,且作为中药提取物,疗效对比试验效果较为理想。To determine the curative effect and the better drug delivery dose of Radix dichroa oral liquid（RDOL）on chicken coccidiosis, 90 Lingnan-yellow chicken were divided into 9 groups randomly with 10 chickens in each group, which including RDOL group （2.5、5.0、15.0、25.0、35.0、50.0 mL/L water, respectively）, toltrazuil group （1.0 mL/L water）, E.tenella infected control group and healthy control group. Every chicken was inoculated 7×10 4 E.tenella oocysts （Guangdong isolates） on 14-day with the exception of the chicken in healthy control group, by administration of drugs through drinking water for 7 days, and the curative effects were observed. Compared with infected control group, the results showed that the cecum and duodenum in RDOL treatments were significantly alleviated, and the blood contents were reduced significantly, the anticoccidial index （ACI） of RDOL treatments were 87.7、136.2、141.8、136.2、109.7 and 108.0, respectively, which were higher than infected control groups. The anticoccidial index of 5.0, 15.0 and 25.0 mL/L water of RDOL group were higher than toltrazuil group （ACI=124.8）. It is showed that RDOL has better anticocidial efficacy rather than toltrazuil under the condition of artificial infection, and the results suggested that RDOL as a kind of herbal extract is expected to become new anticoccidial drugs due to its good anticocidial efficacy.

关 键 词：常山口服液 鸡球虫病 柔嫩艾美耳球虫 抗球虫药 

分 类 号：S853.7[农业科学—临床兽医学]