黄热病疫苗接种后不良反应事件及其监测  

Adverse events following immunization of yellow fever vaccine and surveillance

作　　者：张敏[1] 张瑾[2] 张建明[1] 陆晔[3] 孟菁[4] 曾智娟 何洪涛[1] ZHANG Min;ZHANG Jin;ZHANG Jian-ming;LU Ye;MENG Jing;ZENG Zhi-juan;HE Hong-tao(Guangdong International Travel Heahhcare Center,Guangzhou,Guangdong 510635,China)

机构地区：[1]广东国际旅行卫生保健中心,广东广州510635 [2]山东国际旅行卫生保健中心 [3]上海国际旅行卫生保健中心 [4]四川国际旅行卫生保健中心

出　　处：《中国国境卫生检疫杂志》2018年第3期185-189,共5页Chinese Journal of Frontier Health and Quarantine

基　　金：国家质检总局科技计划项目(2017IK122)

摘　　要：黄热病毒通过蚊虫叮咬传播,在南美洲热带地区和非洲撒哈拉以南地区自然疫源地的灵长类动物体内长期存在。黄热病不定期暴发人间流行,15%的黄热病毒感染者的临床表现重,病死率达20%~50%,无特效治疗药物,疫苗接种是目前预防人类罹患黄热病的有效措施之一。17D黄热病减毒活疫苗已在全球用于预防黄热病多年,其安全性和有效性已被广泛证实,但接种后不良反应事件仍时有报道,某些人群接种17D黄热病减毒活疫苗后相关的神经系统疾病和内脏疾病等严重不良反应的发生率显著升高。对黄热病疫苗接种后不良反应进行合理的监测,将有助于黄热病疫苗在黄热病防控中发挥更大作用。Yellow fever virus is transmitted by mosquito bites between primates. It exists in South America and Sub-Sahara Africa endemic area constantly,and endemics among human population occasionally. Yellow fever is a vaccine preventable disease though it can ＇t be treated by any specific medications with higher fatality（20%-50%）.Yellow fever attenuated vaccine（17D） has been used to prevent the disease worldwide for years. Adverse events following immunization have been reported since then though the consent is that this vaccine is safe and effective.Incidence of yellow fever vaccine-associated neurotropic disease and yellow fever vaccine-associated viscerotropic adverse disease are higher among some vaccinees. So,a proper surveillance on the AEFI is helpful in a safe vaccine administration to contribute a protection as safe as possible. It may help to decrease yellow fever vaccination related severe adverse events to the most extent.

关 键 词：黄热病 疫苗 预防接种 不良反应 

分 类 号：R186.3[医药卫生—流行病学]