活血通络方治疗气阴两虚型糖尿病足临床研究  

Clinical Study of Huoxue Tongluo Prescription in Treating Diabetic Foot with Deficiency of Qi and Yin

作　　者：陈路[1] CHEN Lu(The Second People＇s Hospital of Jingzhou City,Jingzhou Hubei China 43400)

机构地区：[1]荆州市第二人民医院,湖北荆州434000

出　　处：《中医学报》2018年第7期1248-1251,共4页Acta Chinese Medicine

摘　　要：目的:观察活血通络方治疗气阴两虚型糖尿病足患者的临床疗效,并观察其对患者血清炎症因子、血糖、血脂及主要临床指标的影响。方法:80例糖尿病足患者按照完全随机分配原则分为观察组(40例)和对照组(40例)。对照组给予西洛他唑;观察组在对照组治疗基础上给予活血通络方,两组均治疗3个月。治疗后,比较两组患者血管内皮生长因子(vascular endothelial growth factor,VEGF)、白细胞介素-6(interleukin-6,IL-6)、空腹血糖、餐后2小时血糖、胆固醇、三酰甘油(triacylglycerol,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterin,LDL-C)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)水平,记录间歇性跛行距离、肢体抬高试验(Buerger)、踝肱指数(ankle-brachial index,ABI),并比较两组患者临床疗效。结果:观察组有效率为95%,对照组为60%,两组比较,差异有统计学意义(P<0.05)。治疗后,两组患者VEGF、IL-6水平下降,差异有统计学意义(P<0.05);观察组VEGF、IL-6水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组患者间歇性跛行距离、ABI指数均升高,Buerger指数降低,差异均有统计学意义(P<0.01);观察组改善程度显著优于对照组(P<0.05)。治疗后,两组患者空腹血糖和餐后2小时血糖、胆固醇、TG、LDL-C均降低,HDL-C升高,差异有统计学意义(P<0.01);观察组降低血糖效果优于对照组,差异有统计学意义(P<0.05)。结论:活血通络方治疗气阴两虚型糖尿病足临床疗效显著,可显著降低患者VEGF和IL-6水平,降低空腹血糖,改善临床症状。Objective：To observe the clinical effect of Huoxue Tongluo Prescription in treating diabetic foot with deficiency of Qi and Yin,and to observe its effect on serum inflammatory factors,blood glucose,blood lipid and main clinical indexes. Methods：80 patients with diabetic foot were randomly divided into the experimental group（40 cases） and the control group（40 cases）. The experimental group was treated with Huoxue Tongluo Prescription,and the control group was treated with western medicine Cilostazol. Two groups of patients were treated for 3 consecutive months. Detection level of vascular endothelial growth factor（ VEGF） and interleukin-6（ IL-6）,fasting blood glucose value,blood sugar 2 hours after meal,cholesterol（ TC）,triglyceride（ TG）,low density lipoprotein cholesterol（ LDL-C）,high-density lipoprotein cholesterol（ HDL-C）,recording the intermittent claudication distance,body raising test（ Buerger）,ankle brachial index（ ABI） rise in value,and comparison of the clinical curative effect. Results：The effective rate of the experimental group was 95. 00%,the control group was 60. 00%,the difference was statistically significant.The levels of VEGF and IL-6 in the experimental group decreased after treatment,the difference was statistically significant（ P〈0. 05）. There was significant difference in VEGF and IL-6 between the two groups（ P〈0. 05）. Two groups after treatment in patients with intermittent claudication distance,ABI index increases,Buerger index to reduce the difference was statistically significant（ P〈0. 01）,the experimental group compared with control group,the improvement effect is better,the difference was statistically significant（ P〈0. 05）. Two groups after treatment in patients with fasting blood sugar and blood sugar 2 hours after meal,TC,TG,LDL-C were lower,higher HDL-C,compared with before treatment,the difference was statistically significant（ P〈0. 01）,the experimental group hypoglycemic effect was better than that of cont

关 键 词：活血通络方 西洛他唑 气阴两虚证 糖尿病足 炎症因子 血糖 血脂 间歇性跛行距离 肢体抬高试验 踝肱指数 中西医结合 

分 类 号：R259.872[医药卫生—中西医结合]