乌鲁木齐城市和农村绝经后妇女血清维生素D与骨质疏松状况调查  

Vitamin D status and osteoporosis in postmenopausal women of urban and rural areas of Urumqi

作　　者：罗采南[1] 石亚妹[1] 米克拉依[1] 库尔班江[1] 马米娜[1] 王雯婧[1] 雷鑫[1] 刘磊[1] 钟岩[1] 张莉[1] 张伊凤 阿依努尔[1] 武丽君[1] LUO Cainan, SHI Yamei, Mikelayi, Kuerbanjiang, MA Mina, WANG Wenjing, LEI Xin, LIU Lei, ZHONG Yan, ZHANG Li, ZHANG Yifeng, Ayinuer, WU Lijun(People＇s Hospital of Xinjiang Ugyur Autonomous Region, Urumuqi 830001, Chin)

机构地区：[1]新疆维吾尔自治区人民医院,新疆乌鲁木齐830001

出　　处：《中国骨质疏松杂志》2018年第7期940-943,共4页Chinese Journal of Osteoporosis

摘　　要：目的调查乌鲁木齐城市及周边农村绝经后妇女血清25(OH)D水平及骨质疏松状况。方法纳入乌鲁木齐城市及周边农村年龄≥55岁,绝经时间≥1年的女性,收集其一般资料、完成调查问卷、测定血清25(OH)D、甲状旁腺激素(parathyroid hormone,PTH)、碱性磷酸酶(alkaline phosphates,ALP)、Ca、P水平及骨密度。结果 1)符合条件者共231人,其中城市有114人,农村有117人。(2)城市妇女血清25(OH)D水平为17(11.75,23)ng/m L,高于农村妇女15(8,21)ng/m L(P=0.017),且城市妇女中25(OH)D充足人数所占比例高于农村(10.53%vs 3.42%,P=0.033)。(3)在骨量减少和骨质疏松人群中,城市妇女血清25(OH)D_3水平高于农村。(4)血清25(OH)D_3水平在城市妇女中与PTH呈负相关(ρ=-0.247,P=0.008),在农村妇女中与PTH、ALP、白蛋白(albumin,ALB)呈负相关(ρ=-0.344,P<0.001;ρ=-0.193,P=0.037;ρ=-0.202,P=0.029),与腰椎骨密度值呈正相关(ρ=0.195,P=0.035)。结论乌鲁木齐城市与农村绝经后女性骨质疏松的患病率高,维生素D缺乏及不足情况较为普遍。城市和农村绝经后妇女血清维生素D与骨质疏松状况存在差异。Objective To investigate serum 25（OH） D level and osteoporosis status in postmenopausal women of urban and rural areas of Urumqi. Methods Women older than 55 years and menopaused for at least 1 year were enrolled. Demographic information,questionnaire,and data on serum 25（OH） D,PTH,ALP,Ca and P were collected. Results 1） 231 women enrolled in the study,114 from urban and 117 from rural area.（2） Serum 25（OH） D level was 17（11. 75,23） ng/mL in urban women,higher than the that of rural women 15（8,21） ng/mL（P = 0. 017）. The proportion who were 25（OH） D sufficient was higher in urban women than in rural women（10. 53% vs 3. 42%,P = 0. 033）.（3） In those with low bone density or osteoporosis,urban women had higher serum 25（OH） D3 level than those in rural areas.（4） Among women in the urban area,serum 25（OH） D3 level was negatively correlated with PTH（ρ = 0. 247,P = 0. 008）; among women in the rural area,serum 25（OH） D3 level was negatively correlated with PTH,ALP and ALB（ρ = 0. 344,P 〈 0. 001; ρ = 0. 193,P = 0. 037; ρ =-0. 202,P = 0. 029）,and was positively correlated with lumbar vertebrae density（ρ = 0. 195,P = 0. 035）. Conclusion The prevalence of osteoporosis in urban and rural post-menopausal women in Urumqi was high,and vitamin D insufficiency and deficiency are common. There were differences in serum vitamin D and osteoporosis status between urban and rural postmenopausal women in Urumuqi.

关 键 词：骨质疏松 绝经后 维生素D 骨密度 流行病学研究 

分 类 号：R589.5[医药卫生—内分泌]