可溶性钙结合蛋白与肿瘤多药耐药  

Relationship between sorcin and tumor multidrug resistance in tumors

作　　者：勇宇飞 刘克辛 YONG Yufei;LIU Kexin(Department of Clinical Pharmacology,College of Pharmacy,Dalian Medical University,Dalian 116044,China)

机构地区：[1]大连医科大学药学院临床药理教研室,辽宁大连116044

出　　处：《药物评价研究》2018年第6期963-967,共5页Drug Evaluation Research

基　　金：国家自然科学基金资助项目(81473280)

摘　　要：可溶性钙结合蛋白sorcin主要作用是调节细胞内的钙平衡,在肿瘤多药耐药(MDR)中起重要作用。Sorcin不仅自身可导致耐药,而且可通过增加P-糖蛋白(P-gp)表达等途径间接导致耐药,因此可能在临床对肿瘤的治疗中成为逆转肿瘤MDR的靶点。与sorcin相关的治疗MDR的新方法包括反义寡核苷酸转染技术、二氢杨梅素和钙通道阻滞剂治疗等。针对sorcin的作用机制和治疗方法做一综述,为临床逆转MDR提供依据。The main function of sorcin is to regulate intracellular calcium balance and play an important role in multidrug resistance of tumors. Sorcin not only causes drug resistance in itself, but also indirectly leads to drug resistance by increasing the expression of P-gp. Therefore, Sorcin can be clinically used as a target for reversing the multidrug resistance. New methods for the treatment of MDR associated with sorcin include antisense oligonucleotide transfection techniques, treating with dihydromyricetin and calcium channel blocker, and so on. This article reviews the mechanisms and therapies for sorcin so as to provides the basis for the clinical reversal of MDR.

关 键 词：肿瘤多药耐药 可溶性钙结合蛋白 P-糖蛋白 肿瘤化疗 

分 类 号：R962.2[医药卫生—药理学]