药物的跨膜转运机制研究进展  

Research progress on drug transmembrane transport mechanism

作　　者：慈小燕[1] 崔涛[2] 武卫党[1] 谷元[1] 伊秀林[1] CI Xiaoyan;CUI Tao;WU Weidang;GU Yuan;YI Xiulin(State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research New Drug Assessment Co.Ltd.,Tianjin 300193,China;Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津药物研究院新药评价有限公司释药技术与药代国家重点实验室,天津300193 [2]天津中医药大学,天津300193

出　　处：《药物评价研究》2018年第6期973-979,共7页Drug Evaluation Research

基　　金：国家自然科学基金青年科学基金项目(81503154)

摘　　要：机体的最基本单位为细胞,药物的体内动态就是其在体内一系列跨膜转运的综合效果,因此掌握药物跨膜转运的特点和机制非常重要。以往在研究药物的跨膜过程时,多通过其理化性质来分析其跨膜能力。药物的理化性质并不是决定其跨膜能力的唯一因素,生物膜上的蛋白质在其跨膜过程中也起到了重要的、甚至是决定性的作用。主要就细胞膜的结构特点、跨膜转运机制及膜上的主要蛋白进行综述。Cells are the most basic units of organism. Drugs＇ in vivo dynamics are a series of trans-membrane transport in the body of the combined effect, so to master the characteristics and mechanisms of drug transmembrane transport is very important. In the past, when studying the transmembrane process of drugs, most of them analyzed their physical and chemical properties to analyze the transmembrane capabilities. Recent studies have found that the physicochemical properties of drugs are not the only determinants of their transmembrane capacity, and proteins on biomembranes also play an important, even decisive, role in their transmembrane processes. In this paper, the structural characteristics of the cell membrane, transmembrane transport mechanism, and membrane protein are reviewed.

关 键 词：跨膜转运机制 被动转运 转运体介导的跨膜转运 溶质转运体(SLC) ATP结合盒(ABC)转运体 

分 类 号：R962.2[医药卫生—药理学]