阿罗洛尔联合依那普利对充血性心力衰竭的临床疗效研究  

Clinical efficacy of aronixil combined with enalapril in treatment of congestive heart failure

作　　者：刘红梅[1] 翟向伟[2] LIU Hongmei;ZHAI Xiangwei(Internal Department,Baoji People＇s Hospital,Baoji 721000,China;Cardiology Department,Baoji People＇s Hospital,Baoji 721000,China)

机构地区：[1]宝鸡市人民医院内科,陕西宝鸡721000 [2]宝鸡市人民医院心内二科,陕西宝鸡721000

出　　处：《药物评价研究》2018年第6期1086-1089,共4页Drug Evaluation Research

摘　　要：目的研究阿罗洛尔联合依那普利对充血性心力衰竭的临床治疗效果。方法选择2012年1月—2016年12月在宝鸡市人民医院进行诊治的106例充血性心力衰竭患者,随机分为两组,每组53例。对照组口服依那普利治疗,每次5 mg,每天2次,观察组联合口服阿罗洛尔治疗,每次5 mg,每天2次。两组均治疗2个月。比较两组治疗前后的N端脑钠肽前体水平以及左心室射血分数、左心室后壁厚度、左心室舒张末期内径等心功能。结果观察组的有效率为92.45%(49/53),明显高于对照组的77.36%(41/53),差异有统计学意义(P<0.05)。治疗后,两组左心室射血分数明显升高,左心室舒张末期内径和左心室后壁厚度均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组左心室射血分数明显高于对照组,左心室舒张末期内径和左心室后壁厚度均明显低于对照组,差异有统计学意义(P<0.05)。治疗后两组的N端脑钠肽前体水平均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);且观察组明显低于对照组,差异有统计学意义(P<0.05)。两组的不良反应发生率相比无明显差异。结论阿罗洛尔联合依那普利对充血性心力衰竭的临床治疗效果较为显著,可以有效改善患者的心功能,降低N端脑钠肽前体水平,安全有效,值得临床借鉴。Objective To investigate the clinical effect of aronixil combined with enalapril in the treatment of congestive heart failure. Methods Selected 106 cases of patients with congestive heart failure who were treated in our hospital from January 2012 to December 2016, divided into two groups randomly. The control group was treated with enalapril, 5 times a day, 2 times a day. The observation group was treated with aronixil, 5 times a day, 2 times a day. The clinical effects of two groups were compared. The left ventricular ejection fraction, left ventricular end diastolic diameter, left ventricular posterior wall thickness, cardiac function and the level of N end brain natriuretic peptide were measured before and after treatment. Results After treatment, the effective rate of the observation group was 92.45 %（49/53）, significantly higher than that of the control group 77.36%（41/53）（P〈0.05）; the left ventricular ejection fraction, left ventricular end diastolic diameter and left posterior wall thickness of the two groups were significantly improved（P〈0.05）, and the observation group was significantly better than that of the control group（P〈0.05）. After treatment, the levels of N end brain natriuretic peptide in the two groups were significantly lower（P〈0.05）, and the observation group was significantly lower than that of the control group（P〈0.05）. There was no significant difference in the incidence of adverse reactions between the two groups. Conclusion The clinical curative effect of arotinolol combined with enalapril on congestive heart failure is significant, can effectively improve the heart function of patients, reduce the N terminal pro brain natriuretic peptide level, safe and effective, worthy of clinical reference.

关 键 词：阿罗洛尔 依那普利 充血性心力衰竭 临床疗效 

分 类 号：R969.4[医药卫生—药理学]