天然环烯醚萜类化合物的药动学研究进展  

Research progress on pharmacokinetics of natural iridoids

作　　者：郑浩然 褚扬[2,3] 李伟[2,3] 丁黎[1] ZHENG Haoran;CHU Yang;LI Wei;DING Li(Department of Pharmaceutical Analysis,China Pharmaceutical University,Nanjing 210009,China;T asly Academy,Tasly Holding Group Co.,Ltd.,Tianjin 300410,China;State Key Laboratory of Core Technology in Innovative Chinese Medicine,Tasly Holding Group Co.,Ltd.,Tianjin 300410,China)

机构地区：[1]中国药科大学药物分析教研室,江苏南京210009 [2]天士力控股集团有限公司研究院,天津300410 [3]天士力控股集团有限公司创新中药关键技术国家重点实验室,天津300410

出　　处：《药物评价研究》2018年第6期1147-1153,共7页Drug Evaluation Research

基　　金：国家"重大新药创制"科技重大专项(2013ZX09602202)

摘　　要：环烯醚萜类化合物是存在于多种中药材里的一类重要成分,具有多种生物活性。从吸收、分布、代谢、排泄4个方面对常见的环烯醚萜类化合物(栀子苷、胡黄连苷、獐牙菜苦苷等)在动物体内的药动学研究进行整理和综述,发现这类化合物具有在体内快速吸收,在肾、肝等组织脏器中广泛分布,经水解和葡萄糖醛酸化等多种代谢过程后迅速排泄出体外的药动学特点,为提高该类化合物的生物利用度以及新药研发提供参考。Ridoids are important compounds of Chinese medicinal herbs with various biological activities. Pharmacokinetics research of typical iridoid compounds such as geniposide, picroside and swertiamain in recent years was reviewed based on four aspects of absorption, distribution, metabolism and excretion in animals. These compounds are rapidly absorbed, widely distributed in organs such as kidney and liver, metabolized through processes including hydrolysis and glucuronization, and then quickly excreted. This review provides reference for bioavailability improvement and drug development of iridoids.

关 键 词：环烯醚萜 栀子苷 胡黄连苷 獐牙菜苦苷 药动学 生物利用度 

分 类 号：R282.71[医药卫生—中药学]