慢性肾小球肾炎患者血清视黄醇结合蛋白、尿微量白蛋白水平及T淋巴细胞亚群水平的变化及临床意义  

Changes and clinical significance of serum RBP,urine mALB and T lymphocyte subsets in patients with chronic glomerulonephritis

作　　者：白旭[1] 郭利明[1] 谭奎璧[1] 罗群[1] BAI Xu;GUO Liming;TAN Kuibi;LUO Qun(Department of Nephrology,the Second Hospital of Ningbo,Ningbo,Zhejiang 315000,China)

机构地区：[1]宁波市第二医院肾内科,浙江宁波315000

出　　处：《中国卫生检验杂志》2018年第14期1716-1718,共3页Chinese Journal of Health Laboratory Technology

基　　金：浙东区域肾脏病中心[浙卫发(2015)21号]

摘　　要：目的探讨慢性肾小球肾炎患者血清视黄醇结合蛋白(RBP)、尿微量白蛋白(m ALB)水平及T淋巴细胞亚群水平的变化及临床意义。方法选择2014年8月-2016年8月本院收治的慢性肾小球肾炎患者80例作观察组,同期健康体检者60例作对照组,随访1年。比较2组研究对象血清RBP水平、尿液m ALB水平,观察组不同预后RBP水平、尿液m ALB水平,以及T淋巴细胞亚群水平的变化。结果观察组RBP水平及m ALB水平均明显高于对照组;随访观察组患者1年,发展为慢性肾功能衰竭的患者RBP水平及m ALB水平均高于CGN进展不明显或有所缓解的患者;观察组CD3+、CD4+水平、CD4+/CD8+均明显低于对照组,以上差异均有统计学意义(P<0.05)。结论 CGN患者血清RBP和尿液m ALB水平的检测及T淋巴细胞亚群CD3+、CD4+、CD4+/CD8+水平的检测对慢性肾小球肾炎的判断有一定的临床参考价值,更明确的检测结果有待于扩大样本量作进一步研究。Objective To investigate the changes and clinical significance of serum RBP, urine mALB and T lymphocyte subsets in patients with chronic glomerulonephritis. Methods Eighty patients with chronic glomerulonephritis admitted from August 2014 to August 2016 in our hospital were selected as the observation group, and 60 healthy subjects in the same period were selected as the control group. The follow-up period was 1 year. The levels of serum RBP, urine mALB in the two groups were compared, and the levels of serum RBP, urine mALB and lymphocyte subsets in patients of the observation group with different prognosis were compared. Results The levels of RBP and urine mALB in the observation group were significantly higher than that in the control group. After 1 year follow-up in the observation group, the levels of RBP and mALB in patients with chronic renal failure were significantly higher than those in the patients with remission or no obvious progress in CGN. The levels of CD3^＋ CD4^＋ and CD4^＋/CD8^＋ in the observation group were significantly lower than those in the control group, and the above differences were all statistically significant （P〈O.05）. Conclusion The detection of serum RBP and urine mALB and the detection of T lymphocyte subsets in CGN patients have certain clinical reference value for the diagnosis of chronic glomerulonephritis. More clear test results are needed to expand the sample size for further study.

关 键 词：慢性肾小球肾炎 视黄醇结合蛋白 尿微量白蛋白 T淋巴细胞亚群 

分 类 号：R446.6[医药卫生—诊断学]