雷公藤多苷片对缬沙坦在大鼠体内药代动力学的影响  

Effect of tripterysium glycosides tablets on the pharmacokinetics of val-sartan in rats

作　　者：赵俊[1] 徐业[1] 石彦波 黄科[1] 王力勇[1] ZHAO Jun;XU Ye;SHI Yanbo;HUANG Ke;WANG Liyong(Department of Nephrology,Jiaxing Hospital of TCM in Zhejiang Province,Jiaxing 314001,China;Clinical Laboratory,Jiaxing Hospital of TCM in Zhejiang Province,Jiaxing 314001,China)

机构地区：[1]浙江省嘉兴市中医医院肾内科,浙江嘉兴314001 [2]浙江省嘉兴市中医医院实验室,浙江嘉兴314001

出　　处：《中国现代医生》2018年第14期30-33,共4页China Modern Doctor

基　　金：浙江省中医药科技计划资助(2016ZB126)

摘　　要：目的研究大鼠合用雷公藤多苷片和缬沙坦后,雷公藤多苷片对缬沙坦药代动力学的影响。方法 16只雄性SD大鼠,随机分为单独给药组和联合给药组两组,其中单独给药组灌胃缬沙坦(20 mg/kg),联合给药组灌胃雷公藤多苷片(10 mg/kg)和缬沙坦(20 mg/kg)。不同时间点取血并采用LC-MS测定缬沙坦的血药浓度,计算药代动力学参数。结果与单独给药组相比,联合给药组缬沙坦的最大血药浓度[(1.57±0.32)vs(1.01±0.28)μg/m L]和血浆曲线下面积[(10.01±0.58)vs(6.82±0.77)mg·h/L]明显增加(P<0.05),说明缬沙坦的代谢受到明显抑制。结论雷公藤多苷片与缬沙坦联用之后,会对缬沙坦的药代动力学产生明显的影响,本研究对缬沙坦和雷公藤多苷片联合用药具有一定的指导作用,可以避免临床药物不良相互作用的发生。Objective To study the effect of tripterysium glycosides tablets on the pharmacokinetics of valsartan in rats combined with tripterysium glycosides tablets and valsartan. Methods 16 male Sprague-Dawley rats were randomly divided into two groups： the single administration group and the combined administration group. In the single administration group, the rats were given intragastric administration of valsartan（20 mg/kg） and the combined administered group was given intragastric administration of tripterysium glycosides tablets（10 mg/kg） and valsartan（20 mg/kg）. Blood samples were taken at different time points and plasma concentrations of valsartan were determined by LC-MS. Pharmacokinetic parameters were calculated. Results The maximum plasma concentration of valsartan was [（1.57 ±0.32） vs（1.01±0.28）μg/m L] and the plasma area under the curve was [（10.01 ±0.58） vs（6.82±0.77）mg·h/L], which were significantly increased in the combined administration group combined with the single administration group（P〈0.05）, indicating that valsartan metabolism was significantly inhibited. Conclusion Tripterysium glycosides tablets combined with valsartan has a significant effect on the pharmacokinetics of valsartan. This study plays a guiding role in the combined administration of valsartan and tripterygium glycosides tablets, which can avoid the occurrence of clinical adverse drug interactions.

关 键 词：缬沙坦 雷公藤多苷片 药代动力学 药物相互作用 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]