2,3-二取代丙酸衍生物的合成  

Synthesis of 2,3-disubstituted Propanoic Acid Derivatives

作　　者：梁江丽 梁亭 罗强 卢金铭[3] LIANG Jiang-li;LIANG Ting;LUO Qiang;LU Jin-ming(Productivity Promotion Center of Zhangjiakou,Zhangjiakou,Hebei 075000,China;Life Science Research Center of Hebei North University,Zhangjiakou,Hebei 075000,China;Science and Technology College,North China Electric Power University,Baoding,Hebei 071000,China)

机构地区：[1]张家口市生产力促进中心,河北张家口075000 [2]河北北方学院生命科学研究中心,河北张家口075000 [3]华北电力大学科技学院,河北保定071000

出　　处：《河北北方学院学报（自然科学版）》2018年第6期27-30,共4页Journal of Hebei North University:Natural Science Edition

摘　　要：利用取代的苯甲醛和苯乙酸为原料,在三乙胺和乙酸酐作用下经Knoevenagel反应合成潜手性的不饱和酸中间体,再在钯-碳催化加氢作用下得到9种外消旋的2,3-二取代丙酸衍生物,所有化合物均经红外光谱和核磁共振氢谱表征其结构。The prochiral unsaturated acid intermediates were prepared by the materials of substitutional benzaldehyde and phenylacetic acid with the participation of triethylamine and acetic anhydride through Knoevenagel reaction,and then nine racemic derivatives of 2,3-disubstituted propanoic acids were obtained on the condition of Pd-C catalytic hydrogenation.All compounds are characterized by IR spectrum and 1 H-NMR spectrum.

关 键 词：外消旋 2 3-二取代丙酸衍生物 合成 

分 类 号：O621.3[理学—有机化学]