维生素D结合球蛋白临床研究  

Clinical study on vitamin D binding protein

作　　者：刘舒颖 盛志峰[1,2,3] 王湘兵 LIU Shu-ying;SHENG Zhi-feng;WANG Xiang-bing(Department of Metabolism ＆ Endocrinology, the Second Xiangya Hospital, Central South University, Changsha 410011, China;National Clinical Researeh Center for Metabolic Diseases, the Second Xiangy a Hospital, Central South University, Changsha 410011, China;Institution of Metabolism and Endocrinology, Central South University, the second Xiangya Hospital, Central South University, Changsha, 410011, China;Division of Endocrinology, Metabolism ＆ Nutrition, Rutgers University-Robert Wood Johnson Medical School, New Jersey 08901, USA)

机构地区：[1]中南大学湘雅二医院代谢内分泌科,长沙410011 [2]中南大学湘雅二医院代谢内分泌研究所,长沙410011 [3]国家代谢性疾病临床医学研究中心,长沙410011 [4]Division of Endocrinology,Metabolism&Nutrition,Rutgers University-Robert Wood Johnson Medical School,USA New Jersey 08901

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2018年第3期296-304,共9页Chinese Journal Of Osteoporosis And Bone Mineral Research

摘　　要：25羟维生素D(25 hydroxyvitamin D,25OHD)是目前被认为最能代表维生素D营养状态的指标。维生素D在体内的最高活性形式是1,25-双羟维生素D[1,25-dihydroxyvitamin D,1,25(OH)_2D]。血浆中绝大部分25OHD和1,25(OH)2D与维生素D结合蛋白(vitamin D binding protein,DBP)结合,小部分与白蛋白结合,仅有不到1%以非结合形式存在,因此DBP水平的变化可能通过改变25OHD的释放,而影响血浆游离25OHD的水平。本文系统比较了目前用于评估测定总和游离25OHD及DBP的方法,并对其他内分泌激素如何影响DBP和25OHD水平、以及不同生理和病理状态下DBP和25OHD的变化进行综述。As the precursor of the active form of vitamin D, 25 hydroxyvitamin D （25OHD） is regarded as the optimal indicator of vitamin D status. 1, 25-dihydroxy vitamin D [1,25（OH） 2D] is the most active form of vitamin D in vivo. The majority of circulating 25OHD and 1,25（OH）2D is bound to DBP and albumin, with less than 1% persisting in unbound form. Interestingly, a variant in DBP may alter the release of 25OHD and lead to fluctuations in the free 25OHD levels. This paper summarizes the measurements of total and free 25OHD, 25OHD bound to DBP, and 25OHD bound to DBP variant under different physiologic and pathologic conditions.

关 键 词：维生素D结合蛋白 25羟维生素D 维生素D 

分 类 号：R589.5[医药卫生—内分泌]