长周期光栅生物传感器研究进展  

Research progress of biosensors based on long period fiber grating

作　　者：李秋顺 蔡雷 马耀宏 杨俊慧 杨艳 孟庆军 史建国 LI Qiu-shun, CAI Lei, MA Yao-hong, YANG Jun-hui, YANG Yan, MENG Qing-jun, SHI Jian-guo(Qilu University of Technology （Shandong Academy of Sciences ）, Biology Institute of Shandong Academy of Sciences, Key Biosensor Laboratory of Shandong Province ,Ji＇nan 250103, China)

机构地区：[1]齐鲁工业大学(山东省科学院)山东省科学院生物研究所山东省生物传感器重点实验室,山东济南250103

出　　处：《中国光学》2018年第3期475-502,共28页Chinese Optics

基　　金：国家自然科学基金项目(No.61340032;No.61535010;No.31500858);山东省自然科学基金项目(No.ZR2012CM029);山东省重点研发计划项目(No.2016ZDJS07A20);山东省科学院青年基金项目(No.2017QN0010);国家高技术研究发展计划(863计划)资助项目(No.2015AA021005)~~

摘　　要：长周期光纤光栅是对周围环境比较敏感的一种无源光学器件,由于其具有无后向反射、对折射率灵敏度高、体积小、易于集成化、不受电磁干扰、耐酸碱腐蚀、不需要参比电极等诸多特点,在折射率传感领域备受关注。自从2000年Bentley研究组第一次将长周期光纤光栅用于抗原的检测以来,经过十余年的发展,长周期光栅在生物物质的检测方面取得了很大的进展,已被用于抗原抗体、细菌病毒、蛋白质、DNA、酶及核酸等诸多生物物质的检测。本文对长周期光纤光栅近年来在生物传感领域的研究进展和应用进行了总结和评述,并对长周期光纤光栅在生物物质检测方面的未来发展趋势做了展望。Long period fiber grating is a kind of passive optical device which is sensitive to the surrounding environment.Owing to without retroreflection,high sensitivity to refractive index,miniature size,easy integration,immunity to electromagnetic interference,non-corrosiveness,without the need of reference electrode,long period fiber grating based optical sensors have attracted much attention in the field of refractive index sensing.Since Bentley research group first used long period fiber gratings to detect antigens in 2000,long-period gratings have made great progress in the detection of biological substances in recent years and have been utilized for the detection of many biological substances such as antigen-antibody,bacterial viruses,proteins,DNA,enzymes,nucleic acids,and so on.In this paper,the research progress and applications of long period fiber grating in the biosensing field in recent years are summarized and reviewed,and the future development trend of long period fiber grating in biological detection is also prospected.

关 键 词：长周期光栅 生物技术 检测 传感器 进展 

分 类 号：TN253[电子电信—物理电子学] TB383[一般工业技术—材料科学与工程]