突发性耳聋患者血清sVCAM-1水平变化及其意义  

Changes and significance of serum sVCAM-1 level in patients with sudden deafness

作　　者：杨明[1] 伏飞达[1] 朱晓燕[1] YANG Ming, FU Feida, ZHU Xiaoyan(Department of ENT, Nanjing Integrated Traditional Chinese and Western Medicine Hospital, Jiangsu Province, Nanjing 210000, Chin)

机构地区：[1]江苏省南京市中西医结合医院耳鼻喉科,江苏南京210000

出　　处：《中国医药导报》2018年第15期119-122,共4页China Medical Herald

基　　金：江苏省自然科学基金项目(BK2014258)

摘　　要：目的探讨突发性耳聋患者血清可溶性血管细胞黏附分子-1(sVCAM-1)的表达水平及临床意义。方法选择2016年1月~2017年6月南京市中西医结合医院收治的97例突发性耳聋患者作为病例组,并于同期随机选取60名健康体检者为对照组,采用酶联免疫吸附法测定两组血清sVCAM-1水平,并分析其与患者人口学资料的关系以及其对突发性耳聋的诊断价值。结果病例组患者血清sVCAM-1水平高于对照组,差异有统计学意义(P<0.05)。≥45岁患者血清sVCAM-1水平高于<45岁者,听力损失严重患者血清sVCAM-1水平更高,全聋型患者血清sVCAM-1水平高于其他分型,有上呼吸道感染和心脑血管合并症患者血清sVCAM-1水平更高,差异均有统计学意义(P<0.05)。sVCAM-1诊断突发性耳聋的ROC曲线下面积为0.904(95%CI:0.841~0.967),灵敏度为76.5%,特异度为91.8%,此时sVCAM-1的最佳截断值为579.23 ng/mL。结论突发性耳聋患者血清sVCAM-1水平明显升高,其与年龄、听力下降程度、听力曲线、上呼吸道感染、心脑血管合并症密切相关,早期检测可有效预测突发性耳聋的发生。Objective To explore the expression of serum soluble vascular cell adhesion molecule-1（sVCAM-1） and its clinical significance. Methods A total of 97 patients with sudden deafness admitted to Nanjing Integrated Traditional Chinese and Western Medicine Hospital from January 2016 to June 2017 were selected as the case group, 60 healthy subjects were randomly selected as the control group at the same period. The serum sVCAM-1 level in the two groups was measured by the enzyme-linked immunosorbent assay, in addition, the relationship between sVCAM-1 with patients＇ demographic data and the diagnostic value of sVCAM-1 for sudden deafness were analyzed. Results The serum sVCAM-1 level in the case group was higher than that of control group, with statistically significant difference（P〈0.05）. The sVCAM-1 level of patients at the age≥45 was higher than the age45, and sVCAM-1 level in patients with severe hearing loss was more higher, and sVCAM-1 level in patients with total deafness type was more higher than those in other types, sVCAM-1 level of patients with upper respiratory tract infection and cardiovascular complications were more higher, with statistically significant differences（P〈0.05）. The ROC area of sVCAM-1 in the diagnosis of sudden deafness was 0.904（95%CI：0.841-0.967）, the sensitivity was 76.5% and the specificity was 91.8%, the best truncation value of sVCAM-1 at this time was 579.23 ng/m L. Conclusion The serum sVCAM-1 in patients with sudden deafness is significantly elevated, which is closely related to age, hearing loss, hearing curve, upper respiratory tract infection and cerebrovascular complications. Early detection can effectively predict the occurrence of sudden deafness.

关 键 词：突发性耳聋 可溶性血管细胞黏附分子-1 临床意义 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]