参松养心胶囊联合螺内酯治疗慢性心力衰竭的效果观察  

Effect of Shensong Yangxin Capsules combined with Spironolactone in the treatment of chronic heart failure

作　　者：胡永毅[1] 冯力[1] HU Yong-yi;FENG Li(Department of Cardiology,the People＇s Hospital of Zhongshan,Guangdong Province,Zhongshan 528400,China)

机构地区：[1]广东中山市人民医院心血管内科,广东中山528403

出　　处：《中国当代医药》2018年第16期157-160,共4页China Modern Medicine

摘　　要：目的探讨应用参松养心胶囊与螺内酯治疗慢性心力衰竭患者的临床价值。方法选取2016年1月~2017年9月在我院进行治疗的80例慢性心力衰竭患者作为研究对象,采用随机数字表法将其分为两组,每组各40例。对照组患者服用螺内酯治疗,观察组患者在此基础上加用参松养心胶囊进行指标。比较两组患者的心电图指标、心率变异性指标、C-反应蛋白(CRP)与血清N端前脑钠肽(NT-proBNP)水平。结果治疗后,观察组患者的各项心电图指标(QTD、QRS波、QTcd)均低于对照组,差异有统计学意义(P<0.05)。观察组患者的各项心率变异性指标(PNN50、r MSSD、SDANN、SDNN)均高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的CRP[(5.09±1.16)mg/L]、NT-proBNP水平[(567.52±96.33)pg/ml]均低于对照组[(6.29±1.27)mg/L、(716.25±132.64)pg/ml],差异有统计学意义(P<0.05)。治疗后,观察组LVEF[(59.29±5.16)%]高于对照组[(53.02±6.21)%],差异有统计学意义(P<0.05)。结论针对慢性心力衰竭患者,联合参松养心胶囊与螺内酯治疗可有效改善心电图与心率变异性指标,降低CRP与NT-proBNP水平。Objective To explore the clinical value of Shensong Yangxin Capsules combined with Spironolactone in thetreatment of chronic heart failure.Methods A total of 80 patients with chronic heart failure who had received treatmentin our hospital from January 2016 to September 2017 were selected as subjects,and randomly divided into two groupsby random number table method,with 40 cases in each group.The control group was treated with Spironolacton,and theobservation group was treated with Spironolactone combined with Shensong Yangxin Capsules.The electrocardiogramindexs,heart rate variability indexs,the levels of C-reactive protein （CRP） and serum N-terminal pro-B-type natriureticpeptide （NT-proBNP） were compared between the two groups.Results After treatment,electrocardiography （ECG） index-es （QTD,QRS wave,QTcd） in the observation group were lower than those in the control group,and the differences werestatistically significant （P〈0.05）,but the heart rate variability indexes （PNN50,rMSSD,SDANN,SDNN） in the observationgroup were higher than those in the control group,the differences were statistically significant （P〈0.05）.After treatment,thelevels of CRP and NT-proBNP in the observation group were respectively （5.09±1.16） mg/L and （567.52±96.33） pg/ml,which were both lower than those in the control group （[6.29±1.27] mg/L,[716.25±132.64] pg/ml）,the differences werestatistically significant （P〈0.05）.The LVEF in the observation group was （59.29±5.16） %,which was higher than that inthe control group of （53.02±6.21） %,and the difference was statistically significant （P〈0.05）.Conclusion For patientswith chronic heart failure,the combined therapy of Shensong Yangxin Capsules combined with Spironolactone can effec-tively improve the indexes of ECG and heart rate variability,and reduce the levels of CRP and NT-proBNP.

关 键 词：慢性心力衰竭 参松养心胶囊 螺内酯 临床价值 

分 类 号：R259.416[医药卫生—中西医结合]