丙酸氟替卡松联合孟鲁司特钠辅助治疗肺炎支原体感染所致婴幼儿慢性咳嗽的效果分析  

Therapeutic effect of Fluticasone Propionate combined with Montelukast for chronic cough caused by Mycoplasma Pneumoniae in infants

作　　者：陈霞[1] 龙珍[1] 黄洋[1] 舒俊华[1] CHEN Xia;LONG Zhen;HUANG Yang;SHU Jun-hua(Department of Pediatric Respiration,Hubei Maternal and Child Health Hospital,Hubei Province,Wuhan 430070,China)

机构地区：[1]湖北省妇幼保健院儿童呼吸内科,湖北武汉430070

出　　处：《中国当代医药》2018年第16期164-167,共4页China Modern Medicine

摘　　要：目的探讨丙酸氟替卡松吸入气雾剂联合孟鲁司特钠咀嚼片辅助治疗肺炎支原体感染所致婴幼儿慢性咳嗽的效果。方法选取2016年7月~2017年6月我院收治的60例肺炎支原体感染所致慢性咳嗽患儿作为研究对象,将其随机分为对照组和观察组,每组各30例。对照组予以阿奇霉素颗粒治疗,观察组予以阿奇霉素颗粒、丙酸氟替卡松吸入气雾剂和孟鲁司特钠咀嚼片治疗。比较两组患儿治疗第1、7、10、28天的咳嗽症状积分情况并记录咳嗽消失时间,比较两组患儿的临床疗效。治疗结束后再随访3个月,观察两组患儿的咳嗽反复发作次数。结果治疗第1天时,两组患儿的咳嗽症状积分比较,差异无统计学意义(P>0.05)。治疗第7、10、28天时,观察组患儿的咳嗽症状积分均低于对照组,差异有统计学意义(P<0.01)。观察组患儿的治疗总有效率为93.3%,高于对照组的63.3%,差异有统计学意义(P<0.05)。观察组患儿的咳嗽症状消失时间短于对照组,差异有统计学意义(P<0.01)。随访3个月期间,观察组患儿的复发次数少于对照组,差异有统计学意义(P<0.01)。结论丙酸氟替卡松联合孟鲁司特钠辅助治疗婴幼儿肺炎支原体感染所致慢性咳嗽具有显著效果,可明显缩短病程,减少咳嗽复发。Objective To explore the effect of Fluticasone Propionate combined with Montelukast in the treatment of chronic cough caused by Mycoplasma pneumoniae infection in infants.Methods A total of 60 infants with chronic cough caused by Mycoplasma pneumoniae infection treated in our hospital from July 2016 to June 2017 were selected as subjects and randomly divided into the control group and the observation group,30 cases in each group.The control group was treated with Azithromycin Granules,the observation group was treated with Azithromycin Granules,Fluticasone Propionate Inhaled Aerosol and Montelukast Sodium Chewable Tablets.The cough symptomatic scores on the first,seventh,tenth,twenty-eighth days of treatment were compared,and the disappearance time of the cough symptoms were recorded.The clinical efficacy was compared between the two groups.All the children were followed up for 3 months after treatment,the frequency of repeated attacks were observed.Results There was no significant difference in cough symptom scores between the two groups on the first day of treatment（P〉0.05）.The cough symptomatic scores were significantly lower in the observation group than those in the control group on the seventh,tenth,twenty-eighth days of treatment（P〈0.01）.The total clinical effect of the observation groupm was 93.3%,which was obviously higher than that of the control group（63.3%）,the difference was statistically significant（P〈0.05）.The cough disappearance time in the observation group was shorter than that in the control group,the difference was statistically significant（P〈0.01）,and during the follow-up period of 3 months,the number of recurrences of children in the observation group was less than that of the control group,the difference was statistically significant（P〈0.01）.Conclusion Therapy on chronic cough caused by Mycoplasma Pneumoniae infection in infants with combination of Fluticasone Propionate and Montelukast adjuvant has significant effect.

关 键 词：丙酸氟替卡松 孟鲁司特钠 肺炎支原体感染 慢性咳嗽 

分 类 号：R725[医药卫生—儿科]