甲硝唑与山莨菪碱联合补液对慢性肠炎患者血清白细胞介素水平的影响  

Effect of Metronidazole and Anisodamine Combined with Oral Rehydration on Serum Interleukin Levels in Patients with Chronic Enteritis

作　　者：何璐璐[1] 樊萍[1] 杨梅梅[1] 王瑾[1] 徐珽[1] He Lulu;Fan Ping;Yang Meimei;Wang Jin;Xu Ting(Department of Pharmacy,West China Hospital of Sichuan University,Chengdu,Sichuan,China 610041)

机构地区：[1]四川大学华西医院临床药学部,四川成都610041

出　　处：《中国药业》2018年第12期49-51,共3页China Pharmaceuticals

摘　　要：目的探讨甲硝唑、山莨菪碱联合补液治疗慢性肠炎的疗效及血清白细胞介素水平的变化。方法将80例慢性肠炎患者随机分为联合组和对照组,各40例。对照组患者行常规电解质、水和酸碱平衡治疗,有脱水倾向患者口服补液盐和静脉滴注山莨菪碱20 mg,1次/日,连续治疗2周。联合组患者在对照组患者治疗基础上给予0.5 g甲硝唑静脉滴注,1次/日,连续治疗2周。两组患者治疗后均随访至少半年。结果与对照组比较,联合组治愈率和总有效率均提高,治疗1,2周后血清白细胞介素6(IL-6)和白细胞介素8(IL-8)水平均明显降低(P<0.05);与治疗前比较,联合组治疗1,2周后血清IL-6和IL-8水平均明显降低(P<0.05);联合组半年复发率为7.50%,明显低于对照组的25.00%(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05);联合组治疗有效患者治疗前后血清IL-6和IL-8水平均明显降低(P<0.05);联合组复发患者治疗前后血清IL-6和IL-8水平高于未复发患者(P<0.05);Logistic多元回归分析模型分析结果显示,联合组患者治疗前、治疗1周和治疗2周的血清IL-6和IL-8水平与其疗效和复发均相关。结论甲硝唑、山莨菪碱联合补液治疗慢性肠炎的疗效和预后良好,可有效控制炎性反应,且其炎性反应与其疗效和预后相关。Objective To investigate the clinical effect of metronidazole and anisodamine combined with oral rehydration in the treatment of chronic enteritis and its effect on serum interleukin levels.Methods Totally 80 patients with chronic enteritis were randomly divided into the combined group and the control group,40 cases in each group.The control group was given treatment such as routine electrolyte,water and acid-base balance,the patients with dehydrated tendency were treated with oral rehydration salts and intravenous drip of 20 mg anisodamine,once a day for 2 weeks.On the basis of the control group,the combined group was treated with intravenous drip of 0.5 g metronidazole,once a day for 2 weeks.The two groups were followed up for at least half a year after treatment.Results Compared with the control group,the cure rate and total effective rate of the combined group were improved,after 1 week and2 weeks of treatment,the levels of serum IL-6 and IL-8 in the combined group were significantly decreased（P〈0.05）.Compared with before treatment,after 1 week and 2 weeks of treatment,the levels of serum IL-6 and IL-8 in the combined group were significantly decreased（P〈0.05）.The recurrence rate in the combined group was 7.50%,which was significantly lower than 25.00% in the control group（P〈0.05）.There was no significant difference in the incidence rate of adverse reactions between the two groups（P〉0.05）.The levels of serum IL-6 and IL-8 of patients with effective treatment were significantly decreased in the combined group before and after treatment（P〈0.05）.The levels of serum IL-6 and IL-8 of patients with recurrence were significantly higher than those of patients without recurrence in the combined group（P〈0.05）.According to the results of Logistic multivariate regression model analysis,before treatment and after 1 week and 2 weeks of treatment,the levels of serum IL-6 and IL-8 of patients were related to its curative effect and recurrence.Conclusion Metronidazole and anisodamine combin

关 键 词：甲硝唑 山莨菪碱 补液 慢性肠炎 临床疗效 白细胞介素 

分 类 号：R969.4[医药卫生—药理学] R975[医药卫生—药学]