龙海市儿童慢性咳嗽125例过敏原情况调查分析  

Analysis of Allergens Situation in 125 Children With Chronic Cough in Longhai City

作　　者：林益斌 刘裕民 LIN Yibin;LIU Yumin(Department of Paediatries,Longhai No.1 Hospital,Longhai Uujian 363100,China)

机构地区：[1]福建省龙海市第一医院儿科,福建龙海363100

出　　处：《中国卫生标准管理》2018年第12期7-10,共4页China Health Standard Management

基　　金：龙海市科技计划项目(名称:过敏原检测在儿童慢性咳嗽中的应用;项目编号:2016k18)

摘　　要：目的探讨龙海市地区儿童慢性咳嗽常见过敏原的致病状况,为儿童慢性咳嗽流行病学研究及临床诊断、治疗和预防提供重要依据。方法应用阿罗格点刺试液对龙海市地区125例慢性咳嗽患儿进行皮肤点刺试验,分析了5组变应原的阳性率及变应原分布,与年龄、家族过敏史、环境等方面的相关性,并进行统计学处理。结果 125例变应原点试阳性率45.6%。咳嗽变异性哮喘(CVA)阳性率76.0%,感染后咳嗽(PIC)阳性率15.0%,上气道咳嗽综合征(UACS)阳性率40.6%,胃食道返流(GERD)阳性率20.0%,嗜酸粒细胞性支气管炎(EB)阳性率为100.0%。螨类过敏原高于其它过敏原。男女组阳性率比较差异无统计学意义(P>0.05)。≤6岁组与>6岁组阳性率比较差异有统计学意义(P<0.05)。有家族过敏史组与无家族过敏史组阳性率比较差异有统计学意义(P<0.05)。居住环境有危险因素组与无危险因素组阳性率比较差异有统计学意义(P<0.05)。结论过敏是儿童慢性咳嗽的重要因素。螨类为主要过敏原。过敏原阳性率与家族过敏史、居住环境有关。Objective To study the pathogenic of the common allergens of the cause constituents in children with chronic cough in Longhai city, in order to provide evidence for diagnosis and treatment of the children with chronic cough. Methods The skin prick tests were undertaken on 125 children with chronic cough by using the prick reagents provided from Allergophama Company Germany, and the positive rate and allergen distribution of 5 groups of allergens, and their correlation with age, family history of allergy and environment were analyzed, that was statistically processed.Results In 125 cases, the positive rate of the other reagents was 45.6%; the positive rate of cough variant asthma（CVA） was 76.0%, the positive rate of postinfectious cough（PIC） was 15.0%, the positive rate of upper airway cough syndrome（UACS） was 40.6%, the positive rate of gastroesophageal reflux cough（GERC） was 20.0%, and eosinophilic bronchitis（EB） positive rate was 100.0%. The mite allergens is much higher than other allergens; and the positive rates were no significant difference between sex（P〉0.05）; and the positive rates were significant difference between age, ≤ 6 and age 6（P〈0.05）; and the positive rates were significant difference between the groups with family allergy history and groups without family allergy history（P〈0.05）; and the positive rates were significant difference between the living environment with risks and living environment without risks（P〈0.05）. Conclusion Allergens are an important factor in children＇s chronic cough. Then, mites are the major allergen. The positive rate of allergens is related to family allergy history and living environment.

关 键 词：皮肤点刺试验 儿童慢性咳嗽 过敏性疾病 过敏原 

分 类 号：R725[医药卫生—儿科]