工程化软骨几何形状对缺损修复区力学行为的影响  

Geometric shapes of tissue-engineered cartilage exert effects on mechanical behaviors of a defected area

作　　者：赵永政 刘海英 张春秋[1,2] 胡亚辉 Zhao Yong-zheng1,2, Liu Hai-ying1, 2, Zhang Chun-qiu1, 2, Hu Ya-hui1, 2(1.Tianjin Key Laboratory of Advanced Mechatronic System Design and Intelligent Control, Tianjin 300384, China; 2.National Demonstration Center for Experimental Mechanical and Electrical Engineering Education （Tianjin University of Technology）, Tianjin 300384, China)

机构地区：[1]天津市先进机电系统设计与智能控制重点实验室,天津市300384 [2]机电工程国家级实验教学示范中心(天津理工大学),天津市300384

出　　处：《中国组织工程研究》2018年第16期2489-2495,共7页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金青年基金资助项目(11402172);国家自然科学基金重点资助项目(11432016);天津市自然科学重点基金(15JCZJC32800)~~

摘　　要：背景:关节软骨损伤修复结果的不确定性与修复区的力学行为有关,缺损修复的形状、层深及载荷特性均不同程度地改变修复区的力学环境。目的:通过有限元仿真分析在生理载荷作用下关节软骨缺损修复区的力学行为。方法:应用有限元软件ABAQUS建立基于横观各向同性的关节软骨损伤与修复的轴对称模型。分析在压缩载荷作用下,软骨不同修复形状(圆柱、圆台、正棱柱、椭圆柱形)和深度对缺损软骨修复区力学行为的影响。结果与结论:(1)模拟结果表明,不同形状、层深的工程化软骨对软骨修复区力学行为影响规律不同;(2)中间层缺损修复时应力集中现象最显著,深(全)层缺损修复时应力分布较合理;(3)圆柱形工程化软骨修复时的应力场及液相流场分布规律与无损软骨最为接近;临床上,可以选用圆柱形或圆台形工程化软骨进行修复,且尽量避免中间层修复。BACKGROUND： Uncertainty of repairing articular cartilage defects is highly associated with the mechanical behaviors of the defected area, and the mechanical environment varies with the defect shape, depth and load. OBJECTIVE： To study the mechanical behaviors of articular cartilage defects under physiological load by finite element analysis. METHODS： The axisymmetric model of articular cartilage injury and repair based on transversely isotropy was established using ABAQUS software. The mechanical behaviors of the defect zone repaired with different repair shapes（cylindrical, frustum of a cone, orthorhombic prism, elliptical column） and depths of tissue-engineered cartilage under compressive load were analyzed. RESULTS AND CONCLUSION： The simulation results showed that there were significant differences in the mechanical behaviors of the defect area repaired with tissue-engineered cartilage in different shapes and depths. The stress concentration was the most obvious at the middle-layer defect repair, and the stress distribution was more reasonable at the deep（whole） layer defect repair. Furthermore, the distribution of the stress field and the liquid flow field at the cylinder-shaped tissue-engineered cartilage repair was the closest to the normal cartilage. That is to say, the tissue-engineered cartilage in cylinder or frustum-cone shape is recommended to repair cartilage defect. Importantly, the middle-layer repair is inadvisable.

关 键 词：软骨 数值分析 计算机辅助 应力 物理 组织工程 工程化软骨 横观各向同性 软骨缺损 修复 数值模拟 力学行为 组织构建 

分 类 号：R318[医药卫生—生物医学工程]