四种基因位点多态性与运动员耐力表型的关联  

Correlation of four gene polymorphic loci with athlete endurance phenotype

作　　者：魏琦 范家成 杜亚雯 Wei Qi, Fan Jia-cheng, Du Ya-wen(Hubei Institute of Sports Science, Wuhan 430205, Hubei Province, Chin)

机构地区：[1]湖北省体育科学研究所,湖北省武汉市430205

出　　处：《中国组织工程研究》2018年第16期2508-2513,共6页Chinese Journal of Tissue Engineering Research

基　　金：湖北省科技厅科技发展专项课题(KJFZ-2014015)~~

摘　　要：背景:研究表明至少有155个DNA位点多态性都与精英运动员的运动能力表型例如速度和耐力、肌肉力量等有关。目的:分析辅肌动蛋白3(ACTN3)基因、核呼吸因子2(NRF2)基因、β2肾上腺素能受体(ADRB2)基因及过氧化物酶体增殖受体γ共激活剂(PPARGC1A)基因4个基因位点多态性与赛艇运动员有氧能力表型关联及其相互效应,为探讨基因多态性位点作用于耐力表型的机制提供依据。方法:应用Case-Control实验设计,分析4个基因多态性位点在15名优秀赛艇运动员和50名普通大学新生对照组中的分布特征。运用基因型累加分值分析4个基因位点多态性与赛艇运动员有氧能力表型指标的关联。结果与结论:运动员组的辅肌动蛋白3基因、过氧物酶体受体γ共激活剂基因及核呼吸因子2基因位点耐力表现优势基因位点频率均高于对照组,且核呼吸因子2基因位点运动员组与对照组间有显著性差异。3组不同基因型总分运动员组的最大摄氧量均值之间有显著性差异。因此推论研究中3个基因位点多态性可能是预测优秀耐力运动员运动表型的分子标记,作用机制需要进一步验证探讨。BACKGROUND： Increasing evidence shows that at least 155 genetic polymorphisms are associated with aerobic performance and elite endurance athlete status. OBJECTIVE： To study the association of α-actin 3（ACTN3） gene, nuclear respiratory factor 2（NRF2）, β2 adrenergic receptor（ADRB2） gene and peroxisome proliferative activated receptor gamma coactivator 1 alpha（PPARGC1 A） polymorphic loci with aerobic performance of rowing athletes and their interaction effect, thereby providing basis for understanding the mechanism of genetic polymorphisms acting on endurance athlete status. METHODS： A case-control experiment was designed to analyze the distribution characteristics of four gene polymorphism loci in 15 excellent rowing athletes and 50 common college freshmen. The association of four polymorphic loci with the aerobic performance-related indexes was analyzed using total genotype scores. RESULTS AND CONCLUSION： The preponderant polymorphism locus distributions of ACTN3, PPARGC1 A and NRF2 in the athletes group were higher than those in the control group, and the NRF2 gene loci showed significant difference between two groups. In the athletes group, the mean values of VO2 max was significantly different among three genotypes. That is to say, these three genetic polymorphisms may be the biomarkers to predict the elite endurance athlete status, but the mechanism needs to be studied in depth.

关 键 词：基因 表型 组织工程 基因多态性 赛艇 辅肌动蛋白3基因 Β2肾上腺素能受体基因 过氧化物酶体增殖受体γ共激活剂基因 组织构建 核呼吸因子2基因 耐力表型 最大摄氧量 ACTN3 NRF2 ADRB2 PPARGC1A 

分 类 号：R318[医药卫生—生物医学工程]